Three-dimensional magnetic resonance spectroscopic imaging of histologically confirmed brain tumors
Three-dimensional magnetic resonance spectroscopic imaging of histologically confirmed brain tumors
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DOI：
10.1016/s0730-725x(01)00225-9
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发表时间：
2001-01-01
影响因子：
2.5
通讯作者：
Nelson, S
中科院分区：
文献类型：
--
作者：
Vigneron, D;Bollen, A;Nelson, S
本研究的目的是确定手术前用3D磁共振光谱成像（MRSI）测量的代谢物水平是否能准确检测人类脑肿瘤肿块内的活癌。在手术活检和/或切除之前，共研究了31例脑肿瘤患者（33例检查，39例病理相关）。使用PRESS-CSI定位，获得了大部分肿块和邻近脑组织的空间分辨率为0.2至1cc的3D mri。根据切除组织的位置估计胆碱、肌酸和NAA的水平，并将其归一化为正常脑组织。这些数据与随后活检组织样本的组织学分析相关。虽然代谢物比值存在较大差异，但所有确诊癌区均存在显著的胆碱水平，平均胆碱/NAA比值为5.84 + 2.58，最低为1.3。这个最低值比8名正常志愿者的平均值（0.52 +/- 0.13）高出4个标准差。与正常脑组织相比，确诊肿瘤的胆碱信号强度显著升高，平均比值为1.71±0.69。在肿瘤肿块的非增强坏死核心处观察到无显著代谢物水平的光谱。本研究结果表明，脑肿瘤的3D磁共振成像可以检测活癌区域和分级的异常代谢物水平，并可以区分肿瘤与坏死和/或正常脑组织。(C) 2001爱思唯尔科学公司版权所有。
The goal of this study was to determine whether presurgical metabolite levels measured by 3D MR Spectroscopic Imaging (MRSI) can accurately detect viable cancer within human brain tumor masses. A total of 31 patients (33 exams, 39 pathology correlations) with brain tumors were studied prior to surgical biopsy and/or resection. The 3D MRSI was obtained with a spatial resolution of 0.2 to 1 cc throughout the majority of the mass and adjacent brain tissue using PRESS-CSI localization. Levels of choline, creatine and NAA were estimated from the locations of the resected tissue and normalized to normal appearing brain tissue. The data were correlated with subsequent histologic analysis of the biopsy tissue samples. Although there were large variations in the metabolite ratios, all regions of confirmed cancer demonstrated significant choline levels and a mean choline/NAA ratio of 5.84 + 2.58 with the lowest value being 1.3. This lowest value is greater than 4 standard deviations above the mean (0.52 +/- 0.13) found in 8 normal volunteers. The choline signal intensities in confirmed cancers were significantly elevated compared to normal appearing brain tissue with a mean ratio of 1.71 +/- 0.69. Spectra with no significant metabolite levels were observed in the non-enhancing necrotic core of the tumor masses. The results of this study indicate that 3D MRSI of brain tumors can detect abnormal metabolite levels in regions of viable cancer and grades and can differentiate cancer from necrosis and/or normal brain tissue. (C) 2001 Elsevier Science Inc. All rights reserved.