Altered T-cell subsets in HIV-1 natural viral suppressors (elite controllers) with hepatitis C infection.
Altered T-cell subsets in HIV-1 natural viral suppressors (elite controllers) with hepatitis C infection.
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DOI：
10.1097/qad.0b013e328362dea4
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发表时间：
2013-07-31
期刊：
影响因子：
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通讯作者：
Talwani R
中科院分区：
文献类型：
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作者：
Sajadi MM;Redfield RR;Talwani R
We have established a cohort of 64 Natural Viral Suppressors (NVS) (similar to Elite Controllers/Elite Suppressors), 30 of which have chronic HCV. We investigated T cell phenotypic changes in association with HCV infection. NVS without HCV and normal controls had similar T cell phenotypes. However, NVS with HCV had lower naïve cell proportions (CD4 and CD8) compared to NVS without HCV (p=.0008 and p=.02) or normal controls (p=.0163 and p=.017). These results and previous reported data suggest that HCV co-infection increases immune activation and T cell disturbances. Any associated T cell functional changes or potential clinical consequences need further study.
