Sympathetic control of the cerebral vasculature in humans.
Sympathetic control of the cerebral vasculature in humans.
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DOI：
10.1161/strokeaha.109.557132
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发表时间：
2010-01
期刊：
影响因子：
8.3
通讯作者：
Taylor JA
中科院分区：
文献类型：
--
作者：
Hamner JW;Tan CO;Lee K;Cohen MA;Taylor JA
交感神经系统在脑自动调节中的作用仍然缺乏特征。我们研究了在交感神经阻滞和非交感神经阻滞的情况下，脑血流对增强动脉压振荡的反应，并将其与前臂循环中的反应进行了比较。在11名健康受试者中使用40 mmHg振荡下体负压（OLBNP），频率为0.03 - 0.08 Hz，有和无α-肾上腺素能阻滞经酚妥拉明。交感神经阻滞导致平均血压和脑流量不变。在大于0.05 Hz的频率下，脑循环和肱循环的传递函数与动脉压的关系显著增加，但在脑循环的最低频率下，该关系的连贯性仍然很弱。我们的数据表明，一个强大的，频率依赖性的作用，交感神经调节脑循环和肱循环的血流。然而，对阻断反应的显著差异表明，在较长时间尺度上对脑循环的控制的特征在于重要的非线性，并且依赖于交感神经系统以外的调节机制。
The role of the sympathetic nervous system in cerebral autoregulation remains poorly characterized. We examined cerebral blood flow responses to augmented arterial pressure oscillations with and without sympathetic blockade and compared them to responses in the forearm circulation. 40 mmHg oscillatory lower body negative pressure (OLBNP) was used at six frequencies from 0.03 to 0.08 Hz in 11 healthy subjects with and without alpha-adrenergic blockade via phentolamine. Sympathetic blockade resulted in unchanged mean pressure and cerebral flow. The transfer function relationship to arterial pressure at frequencies greater than 0.05 Hz were significantly increased in both the cerebral and brachial circulations, but the coherence of the relation remained weak at the lowest frequencies in the cerebral circulation. Our data demonstrate a strong, frequency dependent role for sympathetic regulation of blood flow in both cerebral and brachial circulations. However, marked differences in the response to blockade suggest the control of the cerebral circulation at longer time scales is characterized by important non-linearities and relies upon regulatory mechanisms other than the sympathetic system.