Multiscale Microtubule Dynamics in Active Nematics
Multiscale Microtubule Dynamics in Active Nematics
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DOI：
10.1103/physrevlett.127.148001
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发表时间：
2021-09-27
影响因子：
8.6
通讯作者：
Dogic, Zvonimir
中科院分区：
文献类型：
--
作者：
Lemma, Linnea M.;Norton, Michael M.;Dogic, Zvonimir
在基于微管的主动向列学中，电机驱动的微管束的伸展运动为混沌的大尺度动力学提供了动力。我们量化了孤立束和密集活动向列相中的细丝间滑动运动。分离的微管对的伸展速度与分子马达的步进速度相当。相反，在密集的2D活动向列相中，网状伸长明显较慢；细丝间的滑动速度广泛分布在平均值附近，细丝既表现为收缩的相对运动，也表现为伸长的相对运动。这些测量突出了将孤立束的延伸率与密集的2D活动向列相中存在的多电机和多丝相互作用联系起来的挑战。它们还提供了建立多尺度模型所必需的定量数据。
In microtubule-based active nematics, motor-driven extensile motion of microtubule bundles powers chaotic large-scale dynamics. We quantify the interfilament sliding motion both in isolated bundles and in a dense active nematic. The extension speed of an isolated microtubule pair is comparable to the molecular motor stepping speed. In contrast, the net extension in dense 2D active nematics is significantly slower; the interfilament sliding speeds are widely distributed about the average and the filaments exhibit both contractile and extensile relative motion. These measurements highlight the challenge of connecting the extension rate of isolated bundles to the multimotor and multifilament interactions present in a dense 2D active nematic. They also provide quantitative data that is essential for building multiscale models.