THE ROLE OF LUNG DEVELOPMENT IN AGE RELATED SUSCEPTIBILITY OF FERRETS TO INFLUENZA VIRUS
THE ROLE OF LUNG DEVELOPMENT IN AGE RELATED SUSCEPTIBILITY OF FERRETS TO INFLUENZA VIRUS
复制标题
肺部发育在雪貂流感病毒年龄相关易感性中的作用
作者：
D. Coates;R. Husseini;D. Rushton;C. Sweet;H. Smith
早期对流感病毒对雪貂影响的研究表明：(I)经鼻接种新生雪貂是普遍致命的，而在15日龄的哺乳或成年动物中，康复是普遍的。(Ii)部分受感染的新生雪貂死亡时有上呼吸道感染的病理证据，但肺部没有实质性损害，(3)新生雪貂肺的器官培养对流感病毒比成年肺更敏感，纤毛上皮比肺泡上皮对流感病毒更敏感。用形态计量学技术研究了这些存活差异可能与生长相关的肺结构的变化有关。这些结果表明：(1)纤毛与肺泡上皮的比例在出生到15天期间减少了一半，随着成年期的增加又减少了一半。(2)在同一时期，支气管壁和细支气管壁的大小增加了，但数量没有增加。这些发现的可能的意义被讨论了与雪貂和人类新生儿和婴儿的关系。
Earlier studies of the effects of influenza virus on the ferret have shown:(i) intranasal inoculation of neonatal ferrets is universally fatal, whereas in 15 day old suckling or adult animals recovery is the rule.(ii) a proportion of the infected neonatal ferrets succumb with pathological evidence of an upper respiratory tract infection but no parenchymal lesions in the lungs, a finding analogous to that in a proportion of human sudden infant deaths (SIDS).(iii) organ cultures of neonatal ferret lung are more susceptible than adult lung and ciliated epithelium is more susceptible than alveolar epithelium to influenza virus.That these differences in survival might be related to changes in the structure of the lung associated with growth was investigated by morphometric techniques. These demonstrated:(i) that the ratio of ciliated to alveolar epithelium halved between birth and 15 days and halved again with the attainment of adulthood.(ii) that the size of the bronchi and bronchioles but not their number increased during the same period. The possible significance of these findings is discussed both in relation to the ferret and human neonate and infant.