Sedative and analgesic effects of medetomidine in dogs--an open clinical study.
Sedative and analgesic effects of medetomidine in dogs--an open clinical study.
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美托咪定对狗的镇静和镇痛作用——一项开放的临床研究。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
A. Adolfsson
中科院分区：
文献类型：
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作者：
L. Nilsfors;L. Garmer;A. Adolfsson
对283只狗进行了美托咪定胃肠外给药，作为镇静和镇痛剂。平均剂量从X线检查的17微克/千克到临床检查的31微克/千克不等。在高于产生足够镇静的剂量下证明了足够的镇痛作用。在给药后15分钟内产生了有效的心动过缓。呕吐发生率为8%。1只犬死亡，尸检时显示慢性肾小球肾炎、心肌坏死和肝充血。
Medetomidine was given parenterally as a sedative and analgesic agent to 283 dogs. Mean doses varied from 17 micrograms/kg for x-ray examinations to 31 micrograms/kg for clinical examinations. An adequate analgesic effect was demonstrated at higher doses than produced sufficient sedation. Potent bradycardia was produced within 15 minutes post administration. No influence of breed, sex or age was found. Vomiting was observed in 8% of the cases. One dog died, showing chronic glomerulonephritis, myocardial necrosis and liver congestion at autopsy.