Synthesis of highly epimerizable N-protected α-amino aldehydes of high enantiomeric excess
Synthesis of highly epimerizable N-protected α-amino aldehydes of high enantiomeric excess
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DOI：
10.1016/s0040-4039(99)02293-5
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发表时间：
2000-02-26
影响因子：
1.8
通讯作者：
Kwon, S
中科院分区：
文献类型：
--
作者：
Myers, AG;Zhong, BY;Kwon, S
The Dess-Martin periodinane was found to be a superior oxidant for the efficient, epimerization-free synthesis of optically active N-protected alpha-amino aldehydes from the corresponding N-protected beta-amino alcohols. Highly racemization-prone products, including N-Fmoc phenylglycinal and N-trifluoroacetyl alpha-amino aldehydes, were prepared in greater than or equal to 95% yield with less than or equal to 1% epimerization. (C) 2000 Elsevier Science Ltd. All rights reserved.
