Extremely well-differentiated adenocarcinoma ("adenoma malignum") of the cervix.
Extremely well-differentiated adenocarcinoma ("adenoma malignum") of the cervix.
复制标题
宫颈高度分化的腺癌（“恶性腺瘤”）。
DOI：
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发表时间：
1983
影响因子：
2.4
通讯作者：
M. Enjoji
中科院分区：
文献类型：
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作者：
T. Kaku;M. Enjoji
本文收集了8例宫颈极高分化腺癌的临床组织病理学研究。尽管肿瘤的组织学外观无害，但其特征是形状不规则，腺体大小不一，腔内乳头状突起由薄结缔组织核心支撑。此外，他们还发现，由于黏液的作用，恶性腺体有明显的突起和膨胀，并向间质中渗漏。临床上，此类肿瘤恶性程度高，预后差。6例患者在手术后3年内死亡。在8个病例中的6个中，Feulgen微量分光光度法DNA测量揭示了与正常宫颈腺相似的模式，除了4c至6c非整倍体细胞。
Eight cases of extremely well-differentiated adenocarcinoma of the cervix were collected for clinicohistopathologic study. The tumors, despite having an innocuous histologic appearance, were characterized by irregular shapes and various sizes of the glands, with intraluminal papillary projections supported by thin connective tissue cores. They showed, in addition, sharp outpouching and distension of the malignant glands by mucin, as well as leakage into stroma. Clinically, such tumors were highly malignant and the prognosis was poor. Six patients died within 3 years following surgical treatment. In six of the eight cases, Feulgen microspectrophotometric DNA measurements disclosed patterns similar to those of normal endocervical glands, except for 4c to 6c aneuploid cells.