Diastolic dysfunction.
Diastolic dysfunction.
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DOI：
10.1253/circj.cj-15-0064
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Dudley SC Jr
中科院分区：
文献类型：
--
作者：
Jeong EM;Dudley SC Jr
尽管受影响的患者越来越多，但对舒张功能障碍和射血分数保留性心力衰竭（HFpEF）的了解仍然很差。主要基于成功治疗收缩性心力衰竭的临床试验令人失望，表明HFpEF与收缩功能障碍的病理学不同。在这篇评论中，一般概念，流行病学，诊断和治疗的舒张功能障碍进行了总结，强调新的实验表明，氧化应激起着至关重要的作用，至少在某些形式的疾病的发病机制。这一观察结果为舒张功能障碍和由舒张功能障碍引起的心力衰竭提供了潜在的新诊断和治疗方法。
Despite the growing number of patients affected, the understanding of diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) is still poor. Clinical trials, largely based on successful treatments for systolic heart failure, have been disappointing, suggesting that HFpEF has a different pathology to that of systolic dysfunction. In this review, general concepts, epidemiology, diagnosis, and treatment of diastolic dysfunction are summarized, with an emphasis on new experiments suggesting that oxidative stress plays a crucial role in the pathogenesis of at least some forms of the disease. This observation has lead to potential new diagnostics and therapeutics for diastolic dysfunction and heart failure caused by diastolic dysfunction.