Yolk-Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic-Plasmonic Hybrid Theranostic Platform
Yolk-Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic-Plasmonic Hybrid Theranostic Platform
复制标题
卵黄壳纳米结构：实现磁等离子体混合治疗平台和谐集成的理想架构
DOI：
10.1002/adma.201606681
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发表时间：
2017-06-06
影响因子：
29.4
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Lin, Li-Sen;Yang, Xiangyu;Chen, Xiaoyuan
磁等离子体杂化纳米粒子（mphn）在癌症治疗中引起了极大的兴趣。然而，在传统的核壳结构mphn中，由于存在一层不透水的涂层，严重限制了质子与磁性部分的接近，磁性成分的弛度通常会被等离子体成分降低。为了解决这个问题，设计了蛋黄壳结构的mphn，该mphn由多孔金外壳包围的空心腔内的Fe3O4核组成。正如预期的那样，在磁性和等离子体部分之间引入空心腔，显著地阻止了Au层引起的Fe3O4核心弛豫度下降。此外，除了赋予等离子体组分高的近红外吸收外，中空的腔体和外壳上的孔隙也可以为抗癌药物提供较大的储存空间和释放通道。此外，多组分纳米颗粒（NPs）仍然具有小于100纳米的紧凑尺寸，以确保有效的肿瘤积聚。综上所述，蛋黄壳Fe3O4@Au NPs可被视为磁共振/光声/正电子发射断层扫描多模态成像和光激活化学热协同治疗的理想磁等离子体治疗平台。
Magnetic-plasmonic hybrid nanoparticles (MPHNs) have attracted great interest in cancer theranostics. However, the relaxivity of the magnetic component is typically reduced by the plasmonic component in conventional core-shell structured MPHNs, due to the presence of a water-impenetrable coating which severely restricts the proximity of protons to the magnetic portion. To circumvent this issue, yolk-shell structured MPHNs comprising a Fe3O4 core within a hollow cavity encircled by a porous Au outer shell are designed. As expected, the introduction of hollow cavity between the magnetic and plasmonic portions significantly prevents the decline in relaxivity of the Fe3O4 core caused by the Au layer. Moreover, in addition to conferring high near-infrared absorption to plasmonic component, the hollow cavity and the pores in the outer shell can also provide a large storage space and release channels for anticancer drugs. Furthermore, the multicomponent nanoparticles (NPs) still have a compact size of less than 100 nm to ensure efficient tumor accumulation. Taken together, the yolk-shell Fe3O4@Au NPs can be regarded as an ideal magnetic-plasmonic theranostic platform for magnetic resonance/photoacoustic/positron emission tomography multimodal imaging and light-activated chemothermal synergistic therapy.