Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness.
Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness.
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DOI：
10.1177/1534735404270335
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发表时间：
2004-12-01
影响因子：
2.9
通讯作者：
Conklin, Kenneth A
中科院分区：
文献类型：
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作者：
Conklin, Kenneth A
抗氧化剂在生物系统中诱导氧化应激。在癌症化疗过程中，氧化应激诱导的脂质过氧化反应产生大量亲电子醛，这些醛可以攻击许多细胞靶点。这些氧化应激产物可以减缓癌细胞的细胞周期进程，并导致细胞周期检查点停滞，这可能会干扰抗癌药物杀死癌细胞的能力。醛类还可以通过灭活死亡受体和抑制半胱天冬酶活性来抑制药物诱导的细胞凋亡（程序性细胞死亡）。这些影响也会降低治疗效果。在化疗期间使用抗氧化剂可以通过减少氧化应激诱导的醛类的产生来增强治疗。
Antineoplastic agents induce oxidative stress in biological systems. During cancer chemotherapy, oxidative stress-induced lipid peroxidation generates numerous electrophilic aldehydes that can attack many cellular targets. These products of oxidative stress can slow cell cycle progression of cancer cells and cause cell cycle checkpoint arrest, effects that may interfere with the ability of anticancer drugs to kill cancer cells. The aldehydes may also inhibit drug-induced apoptosis (programmed cell death) by inactivating death receptors and inhibiting caspase activity. These effects would also diminish the efficacy of the treatment. The use of anti-oxidants during chemotherapy may enhance therapy by reducing the generation of oxidative stress-induced aldehydes.