Phosphine‐Catalyzed Acyl‐Group Exchange Reaction of Carboxylic Acids and an Aroyl Fluoride
Phosphine‐Catalyzed Acyl‐Group Exchange Reaction of Carboxylic Acids and an Aroyl Fluoride
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膦催化的羧酸与芳酰氟的酰基交换反应
DOI：
10.1002/ejoc.202201118
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发表时间：
2022
影响因子：
2.8
通讯作者：
Sakai Norio
中科院分区：
文献类型：
--
作者：
Hattori Hiroyuki;Ishida Kento;Ogiwara Yohei;Sakai Norio
酰氟具有独特的反应活性和稳定性，近年来，以酰氟为催化剂的催化转化反应受到广泛关注，并得到了迅速的研究。因此，不断地需要开发新的酰基氟的合成方法。在此，我们描述了膦催化的羧酸和芳酰氟之间的酰基交换反应。通过由三环己基膦（PCy 3）和2，6-二氟苯甲酰氟组成的催化体系，由羧酸直接获得多种酰氟。本报告是利用酰氟作为脱氧尿苷试剂的第一个例子。
Acyl fluorides show unique reactivity and stability, and the catalytic conversions using acyl fluorides as a divergent building block have recently attracted much attention and have been rapidly researched. Thus, a development of a new synthetic method of acyl fluorides is constantly demanded. Herein, we describe a phosphine‐catalyzed acyl‐group exchange reaction between carboxylic acids and an aroyl fluoride. A variety of acyl fluorides are directly obtained from carboxylic acids through a catalytic system composed of tricyclohexylphosphine (PCy3) and 2,6‐difluorobenzoyl fluoride. This report is the first example of utilizing an acyl fluoride as a deoxyfluorination reagent.