ZIKA VIRUS-INFECTIONS IN NIGERIA - VIROLOGICAL AND SEROEPIDEMIOLOGICAL INVESTIGATIONS IN OYO STATE
ZIKA VIRUS-INFECTIONS IN NIGERIA - VIROLOGICAL AND SEROEPIDEMIOLOGICAL INVESTIGATIONS IN OYO STATE
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DOI：
10.1017/s0022172400025997
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发表时间：
1979-01-01
影响因子：
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通讯作者：
FAGBAMI, AH
中科院分区：
文献类型：
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作者：
FAGBAMI, AH
在尼日利亚奥约州的4个社区开展了一项寨卡病毒感染研究。1971年至1975年间的病毒分离研究从轻度发热疾病的人类病例中分离出2种病毒。血凝抑制试验显示，对寨卡病毒和所使用的其他3种黄病毒的抗体普遍存在。阳性血清的百分比如下：寨卡（31%）、黄热病（50%）、西尼罗河（46%）和韦塞尔斯布朗（59%）。中和试验表明，40%的尼日利亚人有寨卡病毒中和抗体。在有寨卡病毒免疫力的人群中，50%的人仅对寨卡病毒或对寨卡病毒及另外一种黄病毒有中和抗体。共有121份血清有寨卡病毒抗体；其中，48份（40%）还显示对另外2种黄病毒有抗体，12份（10%）对3种或更多其他病毒有抗体。在有寨卡病毒免疫力的血清中，对其他黄病毒的中和抗体百分比分别为：对登革热1型为81%，对黄热病为58%，对韦塞尔斯布朗为7%，对西尼罗河为6%，对乌干达S为3%。
A study of Zika virus infections was performed in 4 communities in Oyo State, Nigeria. Virus isolation studies between 1971 and 1975 yielded 2 virus isolations from human cases of mild febrile illness. Hemagglutination-inhibition tests revealed a high prevalence of antibodies to Zika and 3 other flaviviruses used. The percentages of positive sera were as follows: Zika (31%), yellow fever (50%), West Nile (46%) and Wesselsbron (59%). Neutralization tests showed that 40% of Nigerians had Zika virus neutralizing antibody. Of Zika virus immune persons, 50% had neutralizing antibody to Zika alone or to Zika and 1 other flavivirus. A total of 121 sera had antibody to Zika virus; of these, 48 (40%) also showed antibody to 2 other flaviviruses, and 12 (10%) had antibodies to 3 or more other viruses. The percentage of neutralizing antibodies to other flaviviruses in Zika virus immune sera was 81% to Dengue type 1, 58% to yellow fever, 7% to Wesselsbron, 6% to West Nile and 3% to Uganda S.