Updating appetitive memory during reconsolidation window: critical role of cue-directed behavior and amygdala central nucleus.
Updating appetitive memory during reconsolidation window: critical role of cue-directed behavior and amygdala central nucleus.
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DOI：
10.3389/fnbeh.2013.00186
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发表时间：
2013
影响因子：
3
通讯作者：
Lee HJ
中科院分区：
文献类型：
--
作者：
Olshavsky ME;Song BJ;Powell DJ;Jones CE;Monfils MH;Lee HJ
当呈现光线索，然后是食物时，一些大鼠简单地接近食物杯（Nonorienters），而其他大鼠除了显示食物杯接近行为（Orienters）外，还首先向光定向。线索导向定向可能反映了对线索的注意和/或情感加工的增强，表明定向者和非定向者的线索信息加工具有不同的性质。目前的研究调查线索处理的差异如何可能体现在食欲记忆检索和更新使用的范式开发持续衰减恐惧反应（检索灭绝范式; Monfils等，）。首先，我们研究了是否检索灭绝范式可以减弱食欲反应的Orienters和Nonorienters。接下来，我们研究了在再巩固窗口期间是否可以使用反向学习（恐惧条件反射）来更新食欲记忆（与重复的未强化试验相反，即，灭绝）。灭绝和新的恐惧学习给予的再巩固窗口内持续更新的初始食欲记忆的定向者，但不是Nonorienters有效。由于条件定向是由杏仁中央核（CeA）介导的，我们的最后一个实验研究了CeA在检索-消退过程中的作用。双侧CeA病变干扰了恢复-消退模式，但并不能阻止食物杯法的自发恢复。总之，我们的研究表明，条件定向行为和CeA在更新食欲记忆的再巩固窗口期间的关键作用。
When presented with a light cue followed by food, some rats simply approach the foodcup (Nonorienters), while others first orient to the light in addition to displaying the food-cup approach behavior (Orienters). Cue-directed orienting may reflect enhanced attentional and/or emotional processing of the cue, suggesting divergent natures of cue-information processing in Orienters and Nonorienters. The current studies investigate how differences in cue processing might manifest in appetitive memory retrieval and updating using a paradigm developed to persistently attenuate fear responses (Retrieval-extinction paradigm; Monfils et al.,). First, we examined whether the retrieval-extinction paradigm could attenuate appetitive responses in Orienters and Nonorienters. Next, we investigated if the appetitive memory could be updated using reversal learning (fear conditioning) during the reconsolidation window (as opposed to repeated unreinforced trials, i.e., extinction). Both extinction and new fear learning given within the reconsolidation window were effective at persistently updating the initial appetitive memory in the Orienters, but not the Nonorienters. Since conditioned orienting is mediated by the amygdala central nucleus (CeA), our final experiment examined the CeA’s role in the retrieval-extinction process. Bilateral CeA lesions interfered with the retrieval-extinction paradigm—did not prevent spontaneous recovery of food-cup approach. Together, our studies demonstrate the critical role of conditioned orienting behavior and the CeA in updating appetitive memory during the reconsolidation window.