Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells.
Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells.
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增强的抗肿瘤免疫力需要常驻记忆CD8+T细胞和循环记忆CD8+T细胞之间的相互作用。
DOI：
10.1038/ncomms16073
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发表时间：
2017-07-17
影响因子：
16.6
通讯作者：
Sancho D
中科院分区：
文献类型：
--
作者：
Enamorado M;Iborra S;Priego E;Cueto FJ;Quintana JA;Martínez-Cano S;Mejías-Pérez E;Esteban M;Melero I;Hidalgo A;Sancho D
成功的抗肿瘤免疫的目标是发展长期保护性免疫以防止复发。具有常驻记忆(Trm)表型的CD8+T细胞对肿瘤的侵袭与提高存活率相关。然而，循环CD8+T细胞和Trm细胞之间的相互作用在肿瘤免疫中的研究仍然很少。使用不同的疫苗接种策略来微调Trm细胞或循环记忆T细胞的生成，在这里，我们表明，虽然这两个亚群都足以产生抗肿瘤免疫，但Trm细胞的存在提高了抗肿瘤的效果。被转移的中央记忆T细胞在病毒感染或肿瘤攻击后产生Trm细胞。抗PD-1治疗促进转移的中医药细胞在肿瘤内的渗透，提高抗肿瘤免疫力。此外，依赖于BATF3的树突状细胞对于重新激活循环记忆抗肿瘤反应是必不可少的。我们的发现显示了最佳肿瘤疫苗和免疫治疗所需的记忆CD8+T细胞亚群的可塑性、协作性和重新激活所需的条件。循环记忆细胞包括中央记忆T细胞，保留进入淋巴结的能力，而组织驻留记忆细胞仅限于实质组织。在这里，作者探索了这两种T细胞类型之间的相互作用，并表明两者在抗肿瘤免疫方面都是相互合作的。
The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8+ T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8+ T cells subsets needed for optimal tumour vaccination and immunotherapy. Circulating memory cells include central memory T cells retaining the ability to enter the lymph nodes whereas tissue resident memory cells are confined to the parenchymal tissues. Here the authors explore the interplay between the two T-cell types and show that both cooperate in anti-tumour immunity.
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影响因子：
28.2
作者：
Sánchez-Paulete AR;Cueto FJ;Martínez-López M;Labiano S;Morales-Kastresana A;Rodríguez-Ruiz ME;Jure-Kunkel M;Azpilikueta A;Aznar MA;Quetglas JI;Sancho D;Melero I
通讯作者：
Melero I
DOI：
10.1073/pnas.0503726102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Klebanoff, CA;Gattinoni, L;Restifo, NP
通讯作者：
Restifo, NP
影响因子：
32.4
作者：
Iborra, Salvador;Martinez-Lopez, Maria;Khouili, Sofia C.;Enamorado, Michel;Cueto, Francisco J.;Conde-Garrosa, Ruth;del Fresno, Carlos;Sancho, David
通讯作者：
Sancho, David
影响因子：
4.4
作者：
Djenidi, Faycal;Adam, Julien;Mami-Chouaib, Fathia
通讯作者：
Mami-Chouaib, Fathia
影响因子：
64.8
作者：
Jiang, Xiaodong;Clark, Rachael A.;Liu, Luzheng;Wagers, Amy J.;Fuhlbrigge, Robert C.;Kupper, Thomas S.
通讯作者：
Kupper, Thomas S.