Routes towards Novel Collagen-Like Biomaterials
Routes towards Novel Collagen-Like Biomaterials
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DOI：
10.3390/fib6020021
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发表时间：
2018-04
期刊：
影响因子：
3.9
通讯作者：
Adrian V. Golser;T. Scheibel
中科院分区：
文献类型：
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作者：
Adrian V. Golser;T. Scheibel
胶原蛋白在细胞外基质内提供机械支撑方面发挥着重要作用，因此长期以来被用于各种生物医学目的。例如，它能够替换受损组织而不会对接受患者造成不良反应。如今的胶原蛋白移植物大多由脱细胞和其他加工过的动物组织制成，因此存在不良副作用和机械强度有限的风险，这使得它们不适合某些应用，例如组织工程中。为了改进基于胶原蛋白的生物材料，最近取得了进展，通过受自然启发的丝状纺丝工艺加工可溶性胶原蛋白，并通过生物技术方法和肽合成制造胶原蛋白样蛋白，克服了提供足够量原材料的困难。由于这些方法还开辟了将额外功能域纳入胶原蛋白的可能性，因此我们讨论了性能最好的类胶原蛋白类型之一，其在天然蓝图中已经具有额外的功能域，即海洋贻贝足丝胶原蛋白，为基于胶原丝杂合蛋白的新型生物材料提供了灵感。
Collagen plays a major role in providing mechanical support within the extracellular matrix and thus has long been used for various biomedical purposes. Exemplary, it is able to replace damaged tissues without causing adverse reactions in the receiving patient. Today’s collagen grafts mostly are made of decellularized and otherwise processed animal tissue and therefore carry the risk of unwanted side effects and limited mechanical strength, which makes them unsuitable for some applications e.g., within tissue engineering. In order to improve collagen-based biomaterials, recent advances have been made to process soluble collagen through nature-inspired silk-like spinning processes and to overcome the difficulties in providing adequate amounts of source material by manufacturing collagen-like proteins through biotechnological methods and peptide synthesis. Since these methods also open up possibilities to incorporate additional functional domains into the collagen, we discuss one of the best-performing collagen-like type of proteins, which already have additional functional domains in the natural blueprint, the marine mussel byssus collagens, providing inspiration for novel biomaterials based on collagen-silk hybrid proteins.