Negative regulators of brown adipose tissue (BAT)-mediated thermogenesis.
Negative regulators of brown adipose tissue (BAT)-mediated thermogenesis.
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DOI：
10.1002/jcp.24664
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发表时间：
2014-12
影响因子：
5.6
通讯作者：
Satyanarayana, Ande
中科院分区：
文献类型：
--
作者：
Sharma, Bal Krishan;Patil, Mallikarjun;Satyanarayana, Ande
棕色脂肪组织（BAT）专门用于能量消耗，这一过程称为适应性产热。PET-CT扫描最近证明了成年人中存在代谢活跃的BAT，这重新激发了我们对BAT的兴趣。增加BAT的量和/或活性对于治疗肥胖及其相关疾病具有巨大的希望。PGC 1 α是UCP 1介导的BAT产热的主要调节因子。许多蛋白质通过调节PGC 1 α的表达或转录活性而对产热产生积极或消极的影响。因此，BAT激活可以通过诱导PGC 1 α的正调节因子的表达或通过抑制PGC 1 α/UCP 1通路的阻遏物来实现。本文综述了近年来在BAT介导的产热过程中PGC 1 α/UCP 1信号负调控因子及其作用机制。
Brown adipose tissue (BAT) is specialized for energy expenditure, a process called adaptive thermogenesis. PET-CT scans recently demonstrated the existence of metabolically active BAT in adult humans, which revitalized our interest in BAT. Increasing the amount and/or activity of BAT holds tremendous promise for the treatment of obesity and its associated diseases. PGC1α is the master regulator of UCP1-mediated thermogenesis in BAT. A number of proteins have been identified to influence thermogenesis either positively or negatively through regulating the expression or transcriptional activity of PGC1α. Therefore, BAT activation can be achieved by either inducing the expression of positive regulators of PGC1α or by inhibiting the repressors of the PGC1α/UCP1 pathway. Here, we review the most important negative regulators of PGC1α/UCP1 signaling and their mechanism of action in BAT-mediated thermogenesis.
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DOI：
10.1073/pnas.0808207105
发表时间：
2008-11-04
影响因子：
11.1
作者：
Coste, Agnes;Louet, Jean-Francois;Auwerx, Johan
通讯作者：
Auwerx, Johan
影响因子：
64.8
作者：
Enerback, S;Jacobsson, A;Kozak, LP
通讯作者：
Kozak, LP
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.8
作者：
Delerive, P;Wu, YF;Suen, CS
通讯作者：
Suen, CS
DOI：
10.1073/pnas.0611568104
发表时间：
2007-06-19
影响因子：
11.1
作者：
Dali-Youcef, Nassim;Mataki, Chikage;Auwerx, Johan
通讯作者：
Auwerx, Johan