In utero exposure to Ureaplasma spp. is associated with increased rate of bronchopulmonary dysplasia and intraventricular hemorrhage in preterm infants
In utero exposure to Ureaplasma spp. is associated with increased rate of bronchopulmonary dysplasia and intraventricular hemorrhage in preterm infants
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DOI：
10.1515/jpm.2011.022
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发表时间：
2011-05-01
影响因子：
2.4
通讯作者：
Berger, Angelika
中科院分区：
文献类型：
--
作者：
Kasper, David C.;Mechtler, Thomas P.;Berger, Angelika
目的：我们确定了短期新生儿发病率，如支气管肺发育不良（BPD）和脑室内出血（IVH）与脲原体属之间的关系。方法：对257例孕34周以下剖宫产早产儿的羊水、胎盘及羊膜进行分析。根据支原体检测结果将患者分为两组。通过基于培养的和/或聚合酶链反应（PCR）技术。两组间所有IVH均存在显著差异（P = 0.032）和IVH III或IV级（P = 0.013），与BPD [比值比（OR）5.46，95%可信区间（CI）2.02-14.77]、产后28日龄需氧量威尔斯相同（OR 1.93，95%CI 1.00-3.70），而对于月经后28天至36周或BPD之间的死亡（OR 4.20，95%CI 1.77-9.96）。脲原体属在校正出生体重（P = 0.003）和正压通气（P = 0.001）后，UPA是BPD的显著预测因子（P <0.001）。与早产儿的BPD和IVH相关，即使调整了多种危险因素。
Aims: We determined the association between short-term neonatal morbidities, such as bronchopulmonary dysplasia (BPD) and intraventricular hemorrhage (IVH), and Ureaplasma spp. in amniotic fluid, placental and amniotic membrane of preterm infants.Methods: This study enrolled 257 patients who were born by cesarean section at < 34 weeks' gestation. Patients were divided into two groups according to detection of Ureaplasma spp. by culture-based and/or polymerase chain reaction (PCR) techniques.Results: Significant differences were observed between both groups for all IVH (P = 0.032) and IVH grades III or IV (P = 0.013), as wells as for BPD [odds ratio (OR) 5.46, 95% confidence interval (CI) 2.02-14.77], oxygen requirement at 28 days postnatal age (OR 1.93, 95% CI 1.00-3.70), and for death between 28 days and 36 postmenstrual weeks or BPD (OR 4.20, 95% CI 1.77-9.96). Ureaplasma spp. was a significant predictor (P < 0.001) of BPD after correcting for birth weight (P = 0.003) and positive pressure ventilation (P = 0.001).Conclusions: In our study population Ureaplasma spp. was associated with BPD and IVH in preterm infants even after adjustment for multiple risk factors.