Multidisciplinary treatment of advanced or recurrent solid pseudopapillary neoplasm of the pancreas: three case reports.
Multidisciplinary treatment of advanced or recurrent solid pseudopapillary neoplasm of the pancreas: three case reports.
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DOI：
10.1186/s40792-022-01358-0
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发表时间：
2022-01-10
影响因子：
0.8
通讯作者：
Ohtsuka T
中科院分区：
文献类型：
--
作者：
Tanoue K;Mataki Y;Kurahara H;Idichi T;Kawasaki Y;Yamasaki Y;Kita Y;Hozaka Y;Oi H;Nakajo A;Arigami T;Maemura K;Ohtsuka T
实性假乳头状肿瘤是一种罕见的胰脏肿瘤，主要发生于年轻女性。预后良好;然而，10-15%的患者在手术时出现转移或在胰腺切除术后出现肿瘤复发。我们回顾了3例晚期或复发性SPN患者的临床病程，随后在2002年至2019年期间在我们的机构接受了多学科治疗。所有三名患者的原发肿瘤均被切除，如果有指征，转移瘤也被切除。强化的综合治疗，包括再次切除、化疗、消融、动脉化疗栓塞和放射治疗，使所有患者都能长期生存。文献回顾显示，切除术似乎比其他治疗转移性SPN更有效。包括切除在内的综合治疗可改善复发或转移的SPN患者的预后。
Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor that predominantly affects young females. Prognosis is excellent; however, 10–15% of patients show metastasis at the time of surgery or develop tumor recurrence after pancreatectomy. We reviewed the clinical course of three patients with advanced or recurrent SPN and subsequently underwent multidisciplinary treatment at our institution between 2002 and 2019. The primary tumor was resected in all three patients, and metastases were also resected if indicated. Intensive combined therapy, including re-resection, chemotherapy, ablation, arterial chemoembolization, and radiation therapy, allowed all patients to survive for a long time. The literature review showed that resection seems to be more effective than other treatments for metastatic SPN. Multidisciplinary treatment, including resection, may improve the prognosis of patients with SPN with recurrence or metastasis.