CLONAL ORIGIN OF ATYPICAL ADENOMATOUS HYPERPLASIA OF THE LIVER AND CLONAL IDENTITY WITH HEPATOCELLULAR-CARCINOMA
CLONAL ORIGIN OF ATYPICAL ADENOMATOUS HYPERPLASIA OF THE LIVER AND CLONAL IDENTITY WITH HEPATOCELLULAR-CARCINOMA
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DOI：
10.1016/s0016-5085(88)80093-3
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发表时间：
1988-12-01
期刊：
影响因子：
29.4
通讯作者：
HASEGAWA, H
中科院分区：
文献类型：
--
作者：
TSUDA, H;HIROHASHI, S;HASEGAWA, H
我们报告了两个独立的非典型腺瘤样增生结节性病变的详细情况，其中一个发现了小面积的明显的肝细胞癌。患者血清B型肝炎表面抗原阳性，Southern印迹分析显示，肝细胞癌病灶和周围不典型腺瘤样增生的脱氧核糖核酸显示整合型B型肝炎病毒脱氧核糖核酸的相同限制性图谱，表明两个病灶来源于同一克隆。两个独立的不典型腺瘤样增生病变是由不同细胞克隆性扩增而形成的。
We present details of two separate nodular lesions of atypical adenomatous hyperplasia, within one of which a small area of overt hepatocellular carcinoma was detected. The patient was positive for serum hepatitis B surface antigen, and Southern blot analysis revealed that deoxyribonucleic acid from the lesions of hepatocellular carcinoma and surrounding atypical adenomatous hyperplasia showed the same restriction pattern of integrated hepatitis B virus deoxyribonucleic acid, indicating that the two lesions were derived from an identical clone. It was also indicated that the two separate lesions of atypical adenomatous hyperplasia were independently derived through clonal expansion of different cells.