Hyperinsulinemia: a Cause of Obesity?
Hyperinsulinemia: a Cause of Obesity?
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DOI：
10.1007/s13679-017-0261-z
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发表时间：
2017-06
影响因子：
8.8
通讯作者：
Corkey BE
中科院分区：
文献类型：
--
作者：
Erion KA;Corkey BE
这种观点的动机是需要质疑不起作用的教条：问题是胰岛素抵抗（IR）。我们强调有必要调查潜在的环境致肥胖剂和毒素。严重代谢性疾病的先兆包括三种相互作用的异常组分：（a）IR，（B）血脂升高和（c）基础胰岛素（HI）升高。HI比IR更常见，是糖尿病的重要独立预测因子。我们假设：（1）起始缺陷是HI，其增加了营养消耗和高脂血症（HL）;（2）HI的原因可能包括自1980年以来进入我们食物供应的食品添加剂、环境致胖剂或毒素;以及（3）HI由脂肪量增加引起的HL维持，并导致IR。我们认为HI和HL是代谢功能障碍的早期指标，逆转这些异常可能会防止更严重的代谢疾病的发展。
This perspective is motivated by the need to question dogma that does not work: that the problem is insulin resistance (IR). We highlight the need to investigate potential environmental obesogens and toxins. The prequel to severe metabolic disease includes three interacting components that are abnormal: (a) IR, (b) elevated lipids and (c) elevated basal insulin (HI). HI is more common than IR and is a significant independent predictor of diabetes. We hypothesize that (1) the initiating defect is HI that increases nutrient consumption and hyperlipidemia (HL); (2) the cause of HI may include food additives, environmental obesogens or toxins that have entered our food supply since 1980; and (3) HI is sustained by HL derived from increased adipose mass and leads to IR. We suggest that HI and HL are early indicators of metabolic dysfunction and treating and reversing these abnormalities may prevent the development of more serious metabolic disease.