Donor preconditioning with rabbit anti-rat thymocyte immunoglobulin ameliorates ischemia reperfusion injury in rat kidney transplantation
Donor preconditioning with rabbit anti-rat thymocyte immunoglobulin ameliorates ischemia reperfusion injury in rat kidney transplantation
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DOI：
10.1016/j.trim.2012.03.004
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发表时间：
2012-08-01
影响因子：
1.5
通讯作者：
Raimondi, Clemente
中科院分区：
文献类型：
--
作者：
Cicora, Federico;Roberti, Javier;Raimondi, Clemente
移植的一个主要问题是器官功能的保存。器官缺血时间和微循环障碍不可避免，可能导致缺血再灌注损伤（IRI），增加移植物功能延迟（DGF）和急慢性排斥反应的风险。抗胸腺细胞免疫球蛋白（rATG）是一种多克隆抗体制剂，给药时具有多种作用。我们的目的是评估在同基因大鼠移植实验模型中，给肾供体而不是受体给予rATG是否能改善IRI并促进移植物功能的立即恢复。在接受rATG治疗的供者肾脏中，尿素和肌酐水平及坏死严重程度评分显著降低(尿素：对照组：211 +/- 8 mg/dl与治疗组：110 +/- 15 mg/dl， p
A major concern in transplantation is the preservation of organ function. Ischemia time and microcirculatory disturbance of the organ cannot be avoided and may result in ischemia reperfusion injury (IRI), increasing the risk of delayed graft function (DGF) and acute and chronic rejection. Anti-thymocyte immunoglobulin (rATG) is a polyclonal antibody preparation with multiple effects when administered to recipients. Our objective has been to evaluate whether the administration of rATG to kidney donors instead of recipients, in an experimental model of syngeneic rat transplantation, ameliorates IRI and facilitates immediate graft function recovery. Urea and creatinine levels and necrosis severity scores were significantly lower in kidneys from donors that had received rATG (urea: control: 211 +/- 8 mg/dl vs. treatment: 110 +/- 15 mg/dl, p