Muscle as a Secretory Organ
Muscle as a Secretory Organ
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DOI：
10.1002/cphy.c120033
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发表时间：
2013-07-01
影响因子：
5.8
通讯作者：
Pedersen, Bente K.
中科院分区：
文献类型：
--
作者：
Pedersen, Bente K.
骨骼肌是人体最大的器官。骨骼肌的主要特征是姿势、运动和呼吸所需的机械活动，这取决于肌纤维收缩。然而，骨骼肌不仅仅是我们运动系统的一个组成部分。最近的证据表明骨骼肌是一种分泌器官。我们认为，由肌纤维产生、表达和释放的细胞因子和其他肽类，发挥自分泌、旁分泌或内分泌作用，应归类为“肌因子”。“肌肉分泌体由数百种分泌肽组成。这一发现为理解肌肉如何与脂肪组织、肝脏、胰腺、骨骼和大脑等其他器官进行交流提供了概念基础和全新的范式。此外，几种肌因子在肌肉本身内发挥作用。骨骼肌产生的许多蛋白质依赖于收缩。因此，肌因子可能有助于调节运动的健康益处。(C)2013年美国生理学会。
Skeletal muscle is the largest organ in the body. Skeletal muscles are primarily characterized by their mechanical activity required for posture, movement, and breathing, which depends on muscle fiber contractions. However, skeletal muscle is not just a component in our locomotor system. Recent evidence has identified skeletal muscle as a secretory organ. We have suggested that cytokines and other peptides that are produced, expressed, and released by muscle fibers and exert either autocrine, paracrine, or endocrine effects should be classified as "myokines." The muscle secretome consists of several hundred secreted peptides. This finding provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs such as adipose tissue, liver, pancreas, bones, and brain. In addition, several myokines exert their effects within the muscle itself. Many proteins produced by skeletal muscle are dependent upon contraction. Therefore, it is likely that myokines may contribute in the mediation of the health benefits of exercise. (C) 2013 American Physiological Society.