The independent association of hypertension with cognitive function among older adults with heart failure
The independent association of hypertension with cognitive function among older adults with heart failure
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DOI：
10.1016/j.jns.2012.09.019
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发表时间：
2012-12-15
影响因子：
4.4
通讯作者：
Gunstad, John
中科院分区：
文献类型：
--
作者：
Alosco, Michael L.;Brickman, Adam M.;Gunstad, John
目的：高血压是心力衰竭（HF）患者中最常见的合并症，并且与认知功能障碍独立相关。认知障碍在心衰患者中普遍存在，尽管高血压在多大程度上影响了这一人群的认知功能尚不清楚。方法：116例HF患者（女性31.0%,67.68±11.16岁）完成神经心理测试和阻抗心动图检查。医生诊断的高血压病史，以及其他医学特征，是通过回顾参与者的医疗图表确定的。结果：69.8%的HF患者有高血压诊断史。在调整了人口统计学和医学特征（即心脏指数、用药状况和静息血压）后，高血压与注意/执行功能/精神运动速度独立相关(δ F(1.103) = 10.85, δ R-2 = 0.07, p
Objective: Hypertension is the most common comorbidity among heart failure (HF) patients and has been independently linked with cognitive impairment. Cognitive impairment is prevalent among HF patients, though the extent to which hypertension contributes to cognitive function in this population is unclear.Methods: 116 HF patients (31.0% women, 67.68 +/- 11.16 years) completed neuropsychological testing and impedance cardiography. History of physician diagnosed hypertension, along with other medical characteristics, was ascertained through a review of participants' medical charts.Results: 69.8% of the HF patients had a diagnostic history of hypertension. After adjustment for demographic and medical characteristics (i.e., cardiac index, medication status, and resting blood pressure), hypertension was independently associated with attention/executive function/psychomotor speed (Delta F( 1.103) = 10.85, Delta R-2 = .07, p