New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord
New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord
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DOI：
10.1006/exnr.2001.7827
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发表时间：
2002-01-01
影响因子：
5.3
通讯作者：
Wood, PM
中科院分区：
文献类型：
--
作者：
Casella, GTB;Marcillo, A;Wood, PM
通过层粘连蛋白染色识别的血管在未损伤的脊髓中以及中度挫伤(体重下降)后的2、4、7和14天进行了研究。伤后2天，病变中心血管已被破坏，可见神经元和星形胶质细胞，可见少量ED1+细胞渗入病变中心。4天后，与血管染色相关的层粘连蛋白增加，ED1+细胞在病变中似乎更多。伤后7天，新生血管形成一条纵行穿过损伤中心的连续环状结构。此时ED1+细胞丰富，与新生血管位于同一区域。星形胶质细胞从病变边缘向新的视网膜区迁移明显。14天后，观察到病变中心的血管数量减少；相反，星形胶质细胞在这些区域更加突出。除了为损伤部位提供血液供应外，保护新形成的血管桥的死亡可能提供一个早期的支架，加速损伤部位的轴突再生。(C)2002年爱思唯尔科学公司。
Blood vessels identified by laminin staining were studied in uninjured spinal cord and at 2, 4, 7, and 14 days following a moderate contusion (weight drop) injury. At 2 days after injury most blood vessels had been destroyed in the lesion epicenter; neurons and astrocytes were also absent, and few ED1+ cells were seen infiltrating the lesion center. By 4 days, laminin associated with vessel staining was increased and ED1+ cells appeared to be more numerous in the lesion. By 7 days after injury, the new vessels formed a continuous cordon oriented longitudinally through the lesion center. ED1+ cells were abundant at this time point and were found in the same area as the newly formed vessels. Astrocyte migration from the margins of the lesion into the new cordon was apparent. By 14 days, a decrease in the number of vessels in the lesion center was observed; in contrast, astrocytes were more prominent in those areas. In addition to providing a blood supply to the lesion site, protecting the demise of the newly formed vascular bridge might provide an early scaffold to hasten axonal regeneration across the injury site. (C) 2002 Elsevier Science.