Structural Rearrangements Linked to Global Folding Pathways of the Azoarcus Group I Ribozyme
Structural Rearrangements Linked to Global Folding Pathways of the Azoarcus Group I Ribozyme
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DOI：
10.1016/j.jmb.2008.12.075
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发表时间：
2009-03-06
影响因子：
5.6
通讯作者：
Woodson, Sarah A.
中科院分区：
文献类型：
--
作者：
Chauhan, Seema;Behrouzi, Reza;Woodson, Sarah A.
稳定的rna必须折叠成特定的三维结构才能具有生物活性，然而许多rna形成亚稳态结构，与天然状态竞争。我们之前的时间分辨足迹实验表明偶氮菌I族核酶可以快速形成三级结构（tau）
Stable RNAs must fold into specific three-dimensional structures to be biologically active, yet many RNAs form metastable structures that compete with the native state. Our previous time-resolved footprinting experiments showed that Azoarcus group I ribozyme forms its tertiary structure rapidly (tau