Genetic variants of SLC12A3 modulate serum lipid profiles in a group of Mongolian pedigree population. Lipid in health and disease
Genetic variants of SLC12A3 modulate serum lipid profiles in a group of Mongolian pedigree population. Lipid in health and disease
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DOI：
10.1186/s12944-018-0737-1
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发表时间：
2018
影响因子：
4.5
通讯作者：
Xiulan Su
中科院分区：
文献类型：
--
作者：
Caiyan An;Junqing Liang;Kejin Zhang;Xiulan Su
Background: The serum lipid profile, including LDL-C level, is associated with hypertension which is the major cause of cerebrovascular disease (CVD) amounting 30% of global death rate. Previous work also demonstrated.important roles of genetic variants of SLC12A3 gene on human CVD, hypertension and other diseases in Mongolian population. However, the relationship between SLC12A3 gene polymorphisms on individuals’ lipid profile is still unknown..Methods: A panel of 15 SNPs of SLC12A3 gene was genotyped within a 424 Mongolians pedigree cohort. The associations between SLC12A3 polymorphisms and four lipid profiles were analyzed by family-based association test(FBAT) and confirmed with haplotype analysis..Results: From both single site and haplotype analyses, the results demonstrated a close relationship between SLC12A3 polymorphisms and LDL-C level. Two SNPs, rs5803 and rs711746 showed significant associations with individuals’serum LDL-C level (z=−2.08, P -e =0.038; z=2.09, P -e =0.023, respectively), and distribution of haplotypes constructed by two SNPs also associated with participants’ serum LDL-C level, significantly (Global Chi 2 =9.06 df=3, P=0.028)..Conclusion: Our results demonstrated the importance of SLC12A3 polymorphisms in individuals’ difference about their serum lipid profiles, thereby providing evidence that the genetic variants may contribute to CVD development via modulating person’s LDL-C level and blood pressure, in certain contexts..
