Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome
Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome
复制标题
DOI：
10.1016/s0925-4927(97)00019-x
复制
发表时间：
1997-08-08
影响因子：
2.3
通讯作者：
Reiss, AL
中科院分区：
文献类型：
--
作者：
Kates, WR;Abrams, MT;Reiss, AL
来自众多结构磁共振成像（MRI）研究的证据表明，内侧颞叶结构与几种发育和精神疾病的病理生理学有关。然而，整合这些研究结果的努力受到了挑战，因为在已发表的杏仁核和海马体手动测量方案中缺乏一致性、细节和精确度。在这项研究中，我们描述了一个非常详细的，标准化的协议，测量杏仁核和海马。在本协议的背景下，我们测试了两个经常引用的方法，标准化的杏仁核和海马体的解剖位置测量前的评价者间和评价者内的可靠性。一种方法是创建一个冠状数据集，其中图像在垂直于海马体长轴的平面内旋转。第二种方法包括创建冠状面数据集，其中图像在垂直于连接前后连合的轴的平面内旋转。评价者间和评价者内的可靠性系数（使用组内相关性）范围为0.80至0.98，表明两种位置标准化方法都非常可靠。此外，我们通过比较脆性X综合征儿童的颞叶解剖结构与年龄和性别匹配的一组未受影响的儿童来测试每种方法的有效性。我们发现，当使用旋转方法时，脆性X染色体儿童的海马体积显着增加。这些结果重复了以前的研究结果，表明这两种方法都可以有效地应用于儿科人群的神经解剖学研究。(C)1997 Elsevier Science爱尔兰有限公司
Evidence from numerous structural magnetic resonance imaging (MRI) studies has converged to implicate mesial temporal lobe structures in the pathophysiology of several developmental and psychiatric disorders. Efforts to integrate the results of these studies are challenged, however, by the lack of consistency, detail and precision in published protocols for the manual measurement of the amygdala and hippocampus. In this study, we describe a highly detailed, standardized protocol for measuring the amygdala and the hippocampus. Within the context of this protocol, we tested the inter-and intra-rater reliability of two frequently cited methods for normalizing the anatomical position of the amygdala and hippocampus prior to measurement. One method consisted of creating a coronal data set in which images are rotated in a plane perpendicular to the long axis of the hippocampus. The second method consisted of creating a coronal data set in which images are rotated in a plane perpendicular to the axis connecting the anterior and posterior commissures. Inter-and intra-rater reliability coefficients (using the intraclass correlation) ranged from 0.80 to 0.98, indicating that both methods for positional normalization are highly reliable. In addition, we tested the validity of each method by comparing the temporal lobe anatomy of children with fragile X syndrome to a group of unaffected children matched by age and gender. We found that hippocampal volumes in children with fragile X were significantly increased when either rotational method was used. These results replicated previous findings, suggesting that either method can be validly applied to neuroanatomic studies of pediatric populations. (C) 1997 Elsevier Science Ireland Ltd.