Middle cerebral artery intraplaque hemorrhage: Prevalence and Clinical Relevance
Middle cerebral artery intraplaque hemorrhage: Prevalence and Clinical Relevance
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DOI：
10.1002/ana.22626
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发表时间：
2012-02-01
影响因子：
11.2
通讯作者：
Cui, Li-Ying
中科院分区：
文献类型：
--
作者：
Xu, Wei-Hai;Li, Ming-Li;Cui, Li-Ying
目的：大脑中动脉（MCA）斑块的成分及其与临床状态的关系尚不清楚。使用高分辨率磁共振成像（HR-MRI），我们的目的是检查发生高信号的T1加权脂肪抑制图像（HST 1）的MCA斑块，这是高度提示新鲜或最近的斑块内hemorrhages.Methods：我们回顾性分析了HR-MRI和临床资料的107例成人患者的高度（> 70%）MCA狭窄。在HR-MRI上，MCA斑块内的HST 1被定义为强度>邻近肌肉信号的150%的区域。结果：在981张图像上，共分析了109个狭窄MCA（46个有症状，63个无症状）。HR-MRI显示11支血管（10.1%，9支有症状，2支无症状）中有HST 1。有症状和无症状MCA之间HST 1的发生率有显著差异（19.6% vs 3.2%，p 0.01）。解释：HR-MRI上MCA斑块内的HST 1与同侧卒中相关。我们的研究结果为MCA动脉粥样硬化的血管生物学提供了新的见解。
Objective: Little is known about the composition of middle cerebral artery (MCA) plaques and how they relate to clinical status. Using high-resolution magnetic resonance imaging (HR-MRI), we aimed to examine the occurrence of high signal on T1-weighted fat-suppressed images (HST1) of MCA plaques, which are highly suggestive of fresh or recent intraplaque hemorrhage.Methods: We retrospectively analyzed the HR-MRI and clinical data of 107 adult patients with high-grade (> 70%) MCA stenosis. On HR-MRI, HST1 within an MCA plaque was defined as an area with an intensity > 150% of the signal of adjacent muscles. The relationship between HST1 and clinical presentations was analyzed.Results: A total of 109 stenotic MCAs (46 symptomatic and 63 asymptomatic) on 981 image slices were analyzed. HST1 was revealed on HR-MRI in 11 vessels (10.1%, 9 symptomatic and 2 asymptomatic). The occurrence rate of HST1 between symptomatic and asymptomatic MCAs was significantly different (19.6% vs 3.2%, p 0.01).Interpretation: HST1 within MCA plaque on HR-MRI is associated with ipsilateral stroke. Our results provide new insight into the vascular biology of MCA atherosclerosis.