A novel Robertsonian translocation in a family of Walker hounds.
A novel Robertsonian translocation in a family of Walker hounds.
复制标题
沃克猎犬家族中新颖的罗伯逊易位。
作者：
Stone,DM;Mickelsen,WD;Jacky,PB;Prieur,DJ
一只5岁的沃克犬被送到华盛顿州立大学兽医教学医院，原因是外阴变窄，无法自然繁殖。其他生理和临床表现均正常。细胞遗传学分析显示染色体数目为77，由两条X染色体组成的3条常染色体和2条外中心常染色体（染色体21和33）的罗伯逊易位。对两个未发情的姐妹姐妹进行细胞遗传学分析，发现一个具有相同的易位，另一个具有正常的女性染色体构成。研究人员用染色体核型正常的雄性沃克犬的精液对这只幼崽进行人工授精，并生育了9只正常的幼崽，其中6只雌性和3只雄性。另一只雌性幼崽胎死腹中，但非常正常。细胞遗传学分析显示，9只幼崽中有4只（3只雄性和1只雌性）在所有淋巴细胞中都有相同的易位。其余5只幼崽（5只雌性）具有正常的雌性染色体结构。产仔数是这个品种的平均水平。这是以前未报道的狗的罗伯逊易位。关键词：罗伯逊易位，犬核型，沃克犬
A 5-year-old female Walker hound was presented to the Washington State University Veterinary Teaching Hospital as a result of a narrowing of the vulva, which prevented natural breeding. All other physical and clinical findings were normal. Cytogenetic analysis disclosed a chromosome number of 77, with three metacentric chromosomes comprised of two X chromosomes and a Robertsonian translocation of two acrocentric autosomes, chromosomes 21 and 33. Cytogenetic analysis of two full-sister siblings with histories of absence of estrus disclosed one with the same translocation and one with a normal female chromosome constitution. The propositus was artificially inseminated with semen from a karyotypically normal male Walker hound and gave birth to nine live grossly normal pups, six females and three males. Another female pup was stillborn but was grossly normal. Cytogenetic analysis of the live pups disclosed that four (three males and one female) of the nine had the same translocation in all lymphocytes. The remaining five pups (five females) had normal female chromosome constitutions. The litter size was average for this breed. This is a previously unreported Robertsonian translocation in dogs.Key words: Robertsonian translocation, canine karyotype, Walker hound.