Gastrointestinal permeability during exercise: effects of aspirin and energy-containing beverages
Gastrointestinal permeability during exercise: effects of aspirin and energy-containing beverages
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DOI：
10.1152/jappl.2001.90.6.2075
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发表时间：
2001-06-01
影响因子：
3.3
通讯作者：
Gisolfi, CV
中科院分区：
文献类型：
--
作者：
Lambert, GP;Broussard, LJ;Gisolfi, CV
本研究的目的是确定阿司匹林（A）摄入与长时间运动相结合是否会增加胃肠道通透性，以及摄入含碳水化合物（CHO）或含CHO +谷氨酰胺（CHO+G）的饮料是否会降低这种效应。17名受试者完成了6个实验。他们在前一天晚上和以70%最大摄氧量跑步前60分钟服用A（1，300 mg）或安慰剂（P）药丸。此外，在跑步之前，它们摄入含有5g乳果糖（L）、5g蔗糖（S）和2g鼠李糖（R）的溶液。在每个试验期间，消耗6%CHO饮料、6%CHO +G（0.6%; 41 mM）饮料或水安慰剂（WP）。在运行后4小时，收集所有尿液以测量L、R和S的尿排泄。与所有其他试验相比，在A试验期间，当受试者饮用WP时，S排泄（摄入剂量的百分比;胃十二指肠渗透性的测量）显著更大（P < 0.05）。与所有P试验相比，CHO和WP试验的A给药也显著增加了L/R（肠道通透性的测量）。摄入CHO或CHO+G饮料显著降低S排泄和A给药时的L排泄，但不降低L/R。这些结果表明，胃十二指肠和肠道的通透性增加后，在长时间运行的摄入和摄入的CHO饮料减弱胃十二指肠的影响，但不是肠道的影响。此外，向CHO饮料中添加G在降低胃十二指肠或肠渗透性方面没有提供额外的益处。
The purpose of this study was to determine whether aspirin (A) ingestion combined with prolonged exercise increases gastrointestinal permeability and whether consumption of a carbohydrate-containing (CHO) or a CHO + glutamine-containing (CHO+G) beverage would reduce this effect. Seventeen subjects completed six experiments. They ingested A (1,300 mg) or placebo (P) pills the evening before and before running 60 min at 70% maximal oxygen uptake. Also, before running they ingested a solution containing 5 g lactulose (L), 5 g sucrose (S), and 2 g rhamnose (R). During each trial, either a 6% CHO beverage, a 6% CHO+G (0.6%; 41 mM) beverage, or a water placebo (WP) was consumed. For 4 h after a run, all urine was collected to measure urinary excretion of L, R, and S. S excretion (percentage of dose ingested; measure of gastroduodenal permeability) was significantly greater (P < 0.05) during the A trial while the subjects drank the WP compared with all other trials. Administration of A also significantly increased L/R (measure of intestinal permeability) for the CHO and WP trials compared with all P trials. Ingestion the CHO or CHO+G beverages significantly reduced S excretion and L excretion when A was administered, but it did not reduce L/R. These results indicate that gastroduodenal and intestinal permeability increase after A ingestion during prolonged running and that ingestion of a CHO beverage attenuates the gastroduodenal effect but not the intestinal effect. Furthermore, addition of G to the CHO beverage provided no additional benefit in reducing gastroduodenal or intestinal permeability.