The effects of stress on social preferences are sexually dimorphic in prairie voles
The effects of stress on social preferences are sexually dimorphic in prairie voles
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DOI：
10.1073/pnas.93.21.11980
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发表时间：
1996-10-15
影响因子：
11.1
通讯作者：
Carter, CS
中科院分区：
文献类型：
--
作者：
DeVries, AC;DeVries, MB;Carter, CS
草原田鼠（Microtus ochrogaster）是一种单配型啮齿类动物，其特征是对熟悉的社会伴侣的偏好。在雄性草原田鼠，暴露于压力的游泳或外源性注射皮质酮促进发展的社会偏好的女性与男性配对后注射或游泳。相反，肾上腺切除术抑制男性的伴侣偏好形成，肾上腺切除术的行为效应被皮质酮替代逆转。在雌性草原田鼠中，游泳应激干扰了社会偏好的发展，皮质酮治疗抑制了伴侣偏好的形成，而肾上腺切除的雌性比肾上腺完好的对照组更快地形成偏好。因为在一夫一妻制的物种中，行为和生理上的性别差异通常会减少，伊芙最初预测雄性和雌性草原田鼠对皮质酮会表现出相似的行为反应。然而，我们的研究结果表明，在调节社会偏好的生理过程中，存在一种意想不到的性二态性。这种压力激素在配对结合中的二态参与提供了一种调节社会组织的近似机制，同时允许男性和女性调整其生殖策略以应对环境挑战。
Prairie voles (Microtus ochrogaster) are mo nogamous rodents that form pair bonds characterized by a preference for a familiar social partner. In male prairie voles, exposure to either the stress of swimming or exogenous injections of corticosterone facilitate the development of a social preference for a female with which the male was paired after injection or swimming. Conversely, adrenalectomy inhibits partner preference formation in males and the behavioral effects of adrenalectomy are reversed by corticosterone replacement. In female prairie voles, swim stress interferes with the development of social preferences and corticosterone treatments inhibit the formation of partner preferences, while adrenalectomized females form preferences more quickly than adrenally intact controls. Because sex differences in both behavior and physiology are typically reduced in monogamous species, eve initially predicted that male and female prairie voles would exhibit similar behavioral responses to corticosterone. However, our findings suggest an unanticipated sexual dimorphism in the physiological processes modulating social preferences. This dimorphic involvement of stress hormones in pair bonding provides a proximate mechanism for regulating social organization, while permitting males and females to adapt their reproductive strategies in response to environmental challenges.