Predictive value of antinuclear autoantibodies: The lessons of the systemic sclerosis autoantibodies
Predictive value of antinuclear autoantibodies: The lessons of the systemic sclerosis autoantibodies
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DOI：
10.1016/j.autrev.2008.06.010
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发表时间：
2008-09-01
影响因子：
13.6
通讯作者：
Senecal, Jean-Luc
中科院分区：
文献类型：
--
作者：
Koenig, Martial;Dieude, Melanie;Senecal, Jean-Luc
为系统性硬化症（SSc、硬皮病）患者提供护理的医生会问自己几个问题：SSc 是正确的诊断吗？病程可以预测吗？某些器官受累的风险是否更大？能否预测重要预后？在这篇简短的综述中，我们通过摘录文献中的数据来回答这些问题，重点关注核自身抗原 (ANA) 的 4 种主要 SSc 特异性自身抗体 (aAb)：抗着丝粒 (抗 CENP-B)、抗 Th/To、抗拓扑异构酶 I (抗-topo 1) 和抗 RNA 聚合酶 III (抗-RNAPIII)。数据表明，这些 aAb 作为诊断标志物非常有价值SSc，作为表型子集的生物标志物和预后标志物。我们还确定了未来临床研究的领域。 (C) 2008 Elsevier B.V. 保留所有权利。
Physicians who provide care to patients with systemic sclerosis (SSc, scleroderma) ask themselves several questions: Is SSc the correct diagnosis? Can the disease course be predicted? Is there a greater risk for involvement of certain organs? Can the vital prognosis be predicted? In this brief review, we answer these questions by excerpting data from the literature focused on the 4 major SSc specific autoantibodies (aAbs) to nuclear autoantigens (ANAs): anti-centromere (anti-CENP-B), anti-Th/To, anti-topoisomerase I (anti-topo 1) and anti-RNA polymerase III (anti-RNAPIII).The data show that these aAbs are highly valuable as markers for the diagnosis of SSc, as biomarkers for phenotypic subsets and as prognostic markers. We also identify areas for future clinical research. (C) 2008 Elsevier B.V. All rights reserved.