LIPOIDS OF SERUM IN DIABETIC ACIDOSIS.
LIPOIDS OF SERUM IN DIABETIC ACIDOSIS.
复制标题
糖尿病性酸中毒的血清脂质。
DOI：
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发表时间：
1934
影响因子：
15.9
通讯作者：
J. Peters
中科院分区：
文献类型：
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作者：
E. Man;J. Peters
本科以前的论文(36、42、43)指出，脱水是糖尿病酸中毒临床症状的主要原因，恢复的进程与体内盐分和水分的恢复有关。在目前对糖尿病酸中毒的研究中，将血脂的变化与血清蛋白浓度的变化进行比较有两个原因，即不仅蛋白质是临床改善过程的指示器(42)，而且如果已证明正常的毛细血管对蛋白质和类脂具有同等的不渗透性，那么血液浓度的变化应该会在血浆中产生显著的类脂差异(40)。在每一种情况下，都发现在酸中毒高峰期血清蛋白升高伴随着血清非磷脂脂肪酸、类脂磷和胆固醇的增加，而在恢复期间这四种物质在血清中的浓度均升高。这些成分中的一部分迅速减少。为了试图将这些物质之间的相互关系联系起来，在有和没有糖尿病酸中毒的患者中，胆固醇和非磷脂脂肪酸变化的独立性以及蛋白质和胆固醇行为的相似性变得明显。
It has been pointed out in previous papers from this department (36, 42, 43) that dehydration is largely responsible for the clinical symptoms of diabetic acidosis and that the progress of recovery is correlated with the restoration of the salt and water content of the body. In the present study of diabetic acidosis, changes in lipemia have been compared with variations in serum protein concentration for the double reason that not only are proteins indicative of the course of clinical improvement (42), but also that alterations in hemoconcentration should produce marked differences in the plasma lipoids if normal capillaries are, as has been demonstrated, equally impermeable to proteins and lipoids (40). In every instance, it has been found that the elevation of serum proteins at the height of acidosis is accompanied by an increase of serum non-phospholipoid fatty acids, lipoid phosphorus and cholesterol, and that during recovery the concentrations in blood serum of all four. of these constituents decrease rapidly. In an attempt to correlate the interrelations between these substances, the independence of variations in cholesterol and non-phospholipoid fatty acids and the similarity in behavior of proteins and cholesterol have become apparent in patients both with and without diabetic acidosis.