Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among children.
Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among children.
复制标题
儿童IL6和IL10单倍型与嗜人T淋巴细胞病毒I型感染的易感性
DOI：
10.1086/508783
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Hisada,Michie
中科院分区：
文献类型：
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作者：
Brown,ElizabethE;Brown,BrandonJ;Yeager,Meredith;Welch,Robert;Cranston,Beverly;Hanchard,Barrie;Hisada,Michie
To characterize a host polygenic profile associated with susceptibility to human T lymphotropic virus type I (HTLV-I) infection, we examined common variants in 11 immune-related genes among Jamaican children born to HTLV-I–seropositive mothers. Compared with HTLV-I seronegatives, haplotypes ofIL6(−660G/−635C/−236G) andIL10(−6653C/−1116G) were significantly associated with HTLV-I infection in children independent of maternal provirus load and duration of breast-feeding (odds ratio [OR], 4.5 [95% confidence interval {CI}, 1.2–17.6], and OR, 3.5 [95% CI, 1.4–9.0], respectively). Our findings are the first, to our knowledge, to suggest that host variation in both proinflammatory and anti-inflammatory genes could influence susceptibility to HTLV-I infection
