OPIOID ANTAGONISTS INHIBIT THE GROWTH OF METASTATIC MURINE NEURO-BLASTOMA
OPIOID ANTAGONISTS INHIBIT THE GROWTH OF METASTATIC MURINE NEURO-BLASTOMA
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DOI：
10.1016/0304-3835(83)90087-3
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发表时间：
1983-01-01
期刊：
影响因子：
9.7
通讯作者：
MCLAUGHLIN, PJ
中科院分区：
文献类型：
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作者：
ZAGON, IS;MCLAUGHLIN, PJ
纳曲酮 (NTX) 是一种阿片拮抗剂，对 A/Jax 小鼠 S20Y 神经母细胞瘤 (NB) 的生长有抑制作用。每日注射 0.1 mg/kg NTX 可使肿瘤发生率提高 69%，肿瘤出现时间延迟 70%，中位生存时间延长 60%。在对照小鼠中接种 NB 导致 15 天内 100% 肿瘤消失。 NTX 和对照小鼠的转移模式和发生率相似。这些结果表明 NTX 具有抗肿瘤活性，并表明内源性阿片类药物系统在神经致癌事件中发挥作用。
Naltrexone (NTX), an opiate antagonist, had an inhibitory effect on the growth of S20Y neuroblastoma (NB) in A/Jax mice. Daily injections of 0.1 mg/kg NTX resulted in a 69% tumor take, 70% delay in time prior to tumor appearance, and a 60% increase in median survival time. Inoculation of NB in control mice resulted in 100% tumor take within 15 days. The pattern and incidence of metastases of NTX and control mice were similar. These results show that NTX has antineoplastic activity, and suggests a role for the endogenous opioid system in neuro-oncogenic events.