Lifetime stress experience: transgenerational epigenetics and germ cell programming.
Lifetime stress experience: transgenerational epigenetics and germ cell programming.
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DOI：
10.31887/dcns.2014.16.3/tbale
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发表时间：
2014-09
影响因子：
8.3
通讯作者：
Bale TL
中科院分区：
文献类型：
--
作者：
Bale TL
跨代的表观遗传编程参与通过环境暴露的压力时期，从一代到下一代已在人群中进行了检查，并在动物模型的机械。流行病学研究表明，妊娠期暴露于包括压力在内的环境因素与神经发育障碍的风险增加密切相关，包括注意缺陷多动障碍，精神分裂症和自闭症谱系障碍。母亲和父亲的压力生活经历都可以在怀孕期间直接传递给后代，或者通过生殖细胞中的表观遗传标记传递给后代。父母压力的动物模型研究了相关的后代表型和跨代的结果，并提供了独特的见解生殖细胞表观遗传变化与神经发育中断。了解生殖系在应激暴露过程中对外源性信号的易感性以及鉴定表观遗传标记的类型对于确定疾病风险的潜在机制至关重要。
The transgenerational epigenetic programming involved in the passage of environmental exposures to stressful periods from one generation to the next has been examined in human populations, and mechanistically in animal models. Epidemiological studies suggest that gestational exposures to environmental factors including stress are strongly associated with an increased risk of neurodevelopmental disorders, including attention deficit-hyperactivity disorder, schizophrenia, and autism spectrum disorders. Both maternal and paternal life experiences with stress can be passed on to offspring directly during pregnancy or through epigenetic marks in the germ cell. Animal models of parental stress have examined relevant offspring phenotypes and transgenerational outcomes, and provided unique insight into the germ cell epigenetic changes associated with disruptions in neurodevelopment. Understanding germline susceptibility to exogenous signals during stress exposure and the identification of the types of epigenetic marks is critical for defining mechanisms underlying disease risk.