Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods
Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods
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DOI：
10.1186/s13550-018-0456-7
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发表时间：
2018-12-05
期刊：
影响因子：
3.2
通讯作者：
Buckley, Christopher J.
中科院分区：
文献类型：
--
作者：
Battle, Mark R.;Pillay, Lovena Chedumbarum;Buckley, Christopher J.
简介：定量β-淀粉样蛋白PET示踪剂的标准化方法将允许在不同示踪剂和不同部位之间进行比较。Centiloid量表的开发旨在实现这一目标，应用通用量表以更好地帮助阿尔茨海默病（AD）的诊断和预后，并监测抗淀粉样蛋白治疗干预。在这里，我们应用Centiloid方法[F-18] flutemetaline和[C-11] Pi B（Pi B，匹兹堡化合物B）PET图像，并推导出比例因子，以表达其结合在Centiloids.Methods：配对Pi B和[F-18] flutemetaline扫描74例，包括24名年轻的健康对照（37 +/- 5岁），使用标准Centiloid方法进行了分析。还使用基于PMOD和FSL的管道以及SPM 8分析了相同的主题。结果：采用标准SPM 8 Centiloid方法测定的标准摄取值比值（SUVR）显示[F-18]氟替米特（Flute）与PiB结合之间存在强相关性（SUVR-Flute=0.77 x SUVR-PiB+0.22，R-2=0.96）。应用标准的Centiloid方法可以计算SUVR-Flute到Centiloid单位（CL）的直接转换方程（CL=（121.42*SUVR-Flute）-121.16）。通过两个交替的Centiloid管道对数据进行分析，使我们能够分别推导出PMOD（CL=（115.24*SUVR-Flute）- 107.86）和FSL（CL=（120.32*SUVR-Flute）- 112.75）的标准化SPM 8等效方程。对10AD受试者的重新测试分析显示，每个pipeline.Conclusions的差异约为2%：[F-18] flutemettering数据现在可以用Centiloid单位表示，增强了其在β-淀粉样蛋白成像的临床和研究应用中的实用性。标准的Centiloid方法还证明，与PiB和其他β-淀粉样蛋白示踪剂相比，[F-18] flutemetalide具有有利的性能。重测差异平均为2%，图像处理管道之间无差异。Centiloid缩放是健壮的，可以在许多平台上实现。
Introduction: A standardised method for quantifying beta-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a common scale to better aid the diagnosis and prognosis of Alzheimer's disease (AD) and to monitor anti-amyloid therapeutic interventions. Here, we apply the Centiloid method to [F-18]flutemetamol and [C-11]PiB (PiB, Pittsburgh compound B) PET images and derive the scaling factor to express their binding in Centiloids.Methods: Paired PiB and [F-18]flutemetamol scans for 74 subjects, including 24 young healthy controls (37 +/- 5 years), were analysed using the standard Centiloid method. The same subjects were also analysed using PMOD- and FSL-based pipelines as well as SPM8. Test-retest analysis of 10AD subjects was also performed with each pipeline.Results: The standard uptake value ratios (SUVR), determined using the standard SPM8 Centiloid process, showed a strong correlation between [F-18]flutemetamol (Flute) and PiB binding (SUVR-Flute=0.77 x SUVR-PiB+0.22, R-2=0.96). Application of the standard Centiloid process allowed the calculation of a direct conversion equation for SUVR-Flute to Centiloid units (CL) (CL=(121.42*SUVR-Flute) - 121.16). Analysis of the data via the two alternate Centiloid pipelines allowed us to derive standardised, SPM8-equivalent equations for both PMOD (CL= (115.24*SUVR-Flute) - 107.86) and FSL (CL= (120.32*SUVR-Flute) - 112.75) respectively. Test-retest analysis of 10AD subjects showed an approximate 2% difference for each pipeline.Conclusions: [F-18]flutemetamol data can now be expressed in Centiloid units, enhancing its utility in clinical and research applications for beta-amyloid imaging. The standard Centiloid method also demonstrates that [F-18]flutemetamol has favourable performance compared with PiB and other beta-amyloid tracers. Test-retest difference averaged 2%, with no difference between image processing pipelines. Centiloid scaling is robust and can be implemented on a number of platforms.