Prevalence of periodontal pathogens in localized and generalized forms of early-onset periodontitis
Prevalence of periodontal pathogens in localized and generalized forms of early-onset periodontitis
复制标题
DOI：
10.1034/j.1600-0765.2000.035004232.x
复制
发表时间：
2000-08-01
影响因子：
3.5
通讯作者：
Coulter, WA
中科院分区：
文献类型：
--
作者：
Mullally, BH;Dace, B;Coulter, WA
这项研究的主要目的是调查8种可能的牙周病原体在早发性牙周炎(EOP)患者中的患病率，并评估这种牙周病的局限型和广泛型之间的微生物差异。女性31例，男性11例，平均年龄30.3岁(S.D.4)年。17例全身性牙周炎(GEOP)和25例局限性早发性牙周炎(LEOP)，采用聚合酶链式反应(PCR)检测龈下菌斑，其中福赛氏杆菌78.6%，齿密螺旋体88.1%，伴生放线杆菌19.0%，牙龈卟啉单胞菌16.7%，中间普雷沃特氏菌40.4%，黑色普雷沃特氏菌61.9%，腐蚀性艾氏杆菌42.3%，直肠弯曲杆菌92.8%。只有3个健康部位含有一种或多种牙周病原体。在伴生放线菌阳性的S受试者中，有7人患上了癫痫。58.8%的老年性骨质疏松症患者有中间肺炎支原体，而28%的LEOP患者有中间肺炎支原体(p=0.046)。在82.4%的GEOP位点上发现了黑色假单胞菌，而在LEOP的52%处检测到了这种细菌(p=0.044)。从22.6%的女性受试者中分离到牙龈假单胞菌，但没有男性受试者(p=0.084)。与男性的72.7%相比，所有女性受试者都能恢复直肌(p=0.014)。在非吸烟者中，伴生放线菌(37.5%)和直肠弯曲杆菌(86.5%)的出现率高于吸烟者(7.6%和68.8%)(P
The primary objectives of this study were to investigate the prevalence of 8 putative periodontal pathogens in subjects with early-onset periodontitis (EOP) and to evaluate the microbial differences between localized and generalized forms of this periodontal disease condition. Thirty-one females and 11 males with a mean age of 30.3 (s.d. 4.0) years were examined. Seventeen subjects had generalized (GEOP) and 25 had localized early-onset periodontitis (LEOP), Subgingival plaque samples were assayed using PCR which provided subject prevalence data for the pathogens; Bacteroides forsythus 78.6%, Treponema denticola 88.1%, Actinobacillus actinomycetemcomitans 19.0%, Porphyromonas gingivalis 16.7%, Prevotella intermedia 40.4%, Prevotella nigrescens 61.9%, Eikenella corrodens 42.3% and Campylobacter rectus 92.8%. Only 3 healthy sites harbored one or more of these periodontal pathogens. Seven of the s subjects positive for A. actinomycetemcomitans had LEOP. P. intermedia was present in 58.8% of GEOP compared with 28% of LEOP subjects (p = 0.046). At 82.4% of GEOP sites P. nigrescens was present while this bacteria was detected at 52% of LEOP (p = 0.044). P. gingivalis was isolated from 22.6% of females but no male subjects (p=0.084). C. rectus was recovered from all female subjects compared to 72.7% of males (p = 0.014). A. actinomycetemcomitans (37.5%) and C. rectus (86.5%) were more frequently identified in non-smokers compared to 7.6% and 68.8% of smokers, respectively (p