Pilot Randomized Controlled Trial of Omega-3 and Individual-Family Psychoeducational Psychotherapy for Children and Adolescents With Depression.
Pilot Randomized Controlled Trial of Omega-3 and Individual-Family Psychoeducational Psychotherapy for Children and Adolescents With Depression.
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DOI：
10.1080/15374416.2016.1233500
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Arnold LE
中科院分区：
文献类型：
--
作者：
Fristad MA;Vesco AT;Young AS;Healy KZ;Nader ES;Gardner W;Seidenfeld AM;Wolfson HL;Arnold LE
评估欧米伽-3脂肪酸（Omega-3 fatty acids，EFA）、个体-家庭心理教育心理治疗（individual-family psychoeducational psychotherapy，PEP）及其联合治疗的可行性和效应大小，以及母亲抑郁和心理社会压力对青少年抑郁的调节作用。在一项初步的2X2随机对照试验中，72名患有重度抑郁症、心境恶劣或未另行说明的抑郁症的青年（年龄7-14岁; 57%为白人，57%为男性）被随机分配至12周的PEP、PEP+安慰剂、PEP +PEP或安慰剂组。安慰剂与安慰剂的比较是双盲的。评估者在基线（随机化）和2、4、6、9和12周时使用儿童抑郁评定量表（修订版）评估抑郁严重程度。副作用要么不存在，要么轻微。PEP以74%的保真度施用。缓解率分别为：PEP +PEP组77%; PEP+安慰剂组61%; PEP+安慰剂组44%;安慰剂组56%。意向治疗分析发现，联合治疗（d = 0.29）和单药治疗（d = 0.42）的效果较小至中等，但PEP+安慰剂（d<0.10）的效果可以忽略不计，所有这些都与安慰剂单独治疗相比。与安慰剂相比，社会压力源较少的年轻人对PEP（p = 0.028），PEP（p = 0.035）和PEP（p = 0.04）的反应更好，而那些患有母亲抑郁症的年轻人对PEP（p= 0.020）的反应比那些没有母亲抑郁症的年轻人好。与其他心理治疗研究相比，缓解率是有利的，与现有的随机对照试验（RCT）中的1003相当;结果需要在更大的样本中进行进一步评估。积极治疗显示，在母体抑郁症和更少的压力源的背景下，安慰剂对照抑郁症的改善显着更多，这表明它们可能有利于抑郁症与更多的内源性比环境起源。
Toevaluate feasibility and estimate effect sizes of omega-3 fatty acids (Ω3), individual-family psychoeducational psychotherapy (PEP), their combination, and moderating effects of maternal depression and psychosocial stressors in youth with depression. In a pilot 2X2 randomized controlled trial, 72 youth (ages 7-14; 57% Caucasian, 57% male) with major depression, dysthymia, or depression not-otherwise-specified were randomized to 12 weeks of Ω3, PEP+placebo, Ω3+PEP, or placebo. Ω3 vs. placebo was double-masked. Evaluators masked to condition assessed depressive severity at baseline (randomization), and 2, 4, 6, 9, and 12 weeks using the Children’s Depression Rating Scale-Revised. Side effects were either absent or mild. PEP was administered with 74% fidelity. Remission was: 77%, Ω3+PEP; 61%,PEP+placebo;44%,Ω3; 56%, placebo. Intent-to-treat analyses found small-to medium effects of combined treatment (d = .29) and Ω3 monotherapy (d =.42),but negligible effect for PEP+placebo (d<.10), all comparedto placebo alone. Relative to placebo, youth with fewer social stressors responded better to Ω3 (p=.04), PEP (p=.028), and their combination (p = .035), and those with maternal depression responded better to PEP (p=.020) than did those without maternal depression. Remission rates were favorable compared to other studies of psychotherapy and comparable to an existing RCT of Ω3; results warrant further evaluation in a larger sample.Ω3 was well-tolerated. Active treatments show significantly more placebo-controlled depression improvement in the context of maternal depression and fewer stressors, suggesting they may benefit depression with a more endogenous than environmental origin.
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DOI：
10.1097/00004583-198909000-00013
发表时间：
1989-09-01
影响因子：
13.3
作者：
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2006-12-01
影响因子：
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DOI：
10.1097/chi.0b013e3181977476
发表时间：
2009-03-01
影响因子：
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