Incidence of amyotrophic lateral sclerosis in southern Italy: a population based study
Incidence of amyotrophic lateral sclerosis in southern Italy: a population based study
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DOI：
10.1136/jnnp.2004.039180
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发表时间：
2005-08-01
影响因子：
11
通讯作者：
Serlenga, L
中科院分区：
文献类型：
--
作者：
Logroscino, G;Beghi, E;Serlenga, L
背景：虽然肌萎缩性侧索硬化症（ALS）的发病率在世界范围内相似（范围为1.0至2.5/100000），但已观察到从北到南的纬度梯度。目的：确定意大利东南部普利亚地区ALS的发病率，并将本研究与在北纬地区进行的相同设计的研究结果进行比较，检验纬度梯度假设。方法：Puglia（2001年有4086613名居民）是1997年建立的多中心、多来源前瞻性人口登记中心。在1998-99年期间，所有ALS病例都被登记并随访。使用第一种和经修订的El Escorial标准对病例进行分类。结果：研究期间共纳入病例130例。1998- 1999年两年间，普利亚地区ALS的年粗发病率为1.6/100000（95%可信区间为1.3 - 1.9）。在所有年龄组中，男性的发病率(发病率(IR)=2.1（1.7至2.7）高于女性（IR=1.2(0.9至1.5)），男女比例为1.6。男性和女性的发病率在75岁之前都有所增加，之后迅速下降。2001年意大利人口按年龄和性别调整后的年平均发病率为1.7/100000（1.4至2.0）。结论：各国ALS发病率范围较窄，65 - 75岁为高峰，男性发病率较高。队列研究的结果不支持ALS发病率从北向南的纬度梯度。
Background: While the incidence of amyotrophic lateral sclerosis (ALS) is similar across the world (range, 1.0 to 2.5/100000), a latitude gradient from north to south has been observed.Objective: To determine the incidence of ALS in Puglia, a region of south eastern Italy, and to test the latitude gradient hypothesis comparing the present study with findings in studies conducted with the same design in a northern latitude.Methods: Puglia (4086613 residents in 2001) is the site of a multicentre-multisource prospective population based registry established in 1997. All incident ALS cases during the period 1998-99 were enrolled and followed up. Cases were classified using the first and the revised El Escorial criteria.Results: During the study period 130 cases were enrolled. The annual crude incidence for ALS in Puglia for the two year period 1998-99 was 1.6/100000 (95% confidence interval, 1.3 to 1.9). The incidence was higher for men (incidence rate (IR)=2.1 (1.7 to 2.7) than for women (IR=1.2 (0.9 to 1.5)) in all age groups, with a male to female ratio of 1.6. For both men and women, the incidence increased through age 75 and declined rapidly afterwards. The mean annual incidence adjusted by age and sex to the 2001 Italian population was 1.7/100000 (1.4 to 2.0).Conclusions: ALS incidence is within a narrow range across countries, with a peak between 65 and 75 years and a higher incidence in men. A north to south latitude gradient of ALS incidence is not supported by the results of cohort studies.