Continuous Pilot-Scale Wet-Spinning of Biocompatible Chitin/Chitosan Multifilaments from an Aqueous KOH/Urea Solution.
Continuous Pilot-Scale Wet-Spinning of Biocompatible Chitin/Chitosan Multifilaments from an Aqueous KOH/Urea Solution.
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DOI：
10.1002/marc.202100252
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发表时间：
2021-06
影响因子：
4.6
通讯作者：
Junchao Huang;Yi Zhong;Xi Zhang;Huan Xu;Caizhen Zhu;J. Cai
中科院分区：
文献类型：
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作者：
Junchao Huang;Yi Zhong;Xi Zhang;Huan Xu;Caizhen Zhu;J. Cai
甲壳素是一种很有前途的天然高分子材料，在生物医学、卫生学、吸附剂和食品包装等方面具有很大的应用潜力。生产甲壳素复丝并将其组装成纺织品是制备这些材料的有效方法，湿法纺丝是用于生产人造纤维的主要方法。然而，甲壳素的溶解、甲壳素原液的稳定性和长丝强度的保证是甲壳素复丝生产的主要障碍。基于最近对甲壳素溶解、溶液性质和高强度甲壳素基材料的研究，甲壳素复丝湿法纺丝不再仅仅是一种假设的策略。在这里，中试规模的湿法纺丝方法，介绍了克服上述限制。通过在KOH/尿素水溶液中溶解和老化制备稳定的甲壳素纺丝原液。采用中试湿法纺丝装置和醇/盐水凝聚法制备了甲壳素复丝。脱乙酰化后的壳聚糖复丝结构致密，结晶度低，但力学性能优异。甲壳素/壳聚糖复丝具有良好的细胞相容性，在生物医学领域具有广阔的应用前景。该方法为甲壳素/壳聚糖湿法纺丝的中试提供了一种新的途径。
Chitin is a promising natural polymer with great potential as a biomedical, hygiene, absorbent, and food-packing material. Producing chitin multifilament and assembling them into textiles is an efficient way of preparing these materials, with wet-spinning a major method used to produce man-made fibers. Unfortunately, dissolving chitin, producing a stable and suitable chitin dope, and ensuring filament strength are the main obstacles to the production of chitin multifilament. Based on recent research into chitin dissolution, solution properties, and high-strength chitin-based materials, chitin multifilament wet-spinning is no longer only a hypothetical strategy. Here, a pilot-scale wet-spinning method is introduced that overcomes the abovementioned limitations. A stable chitin spinning dope is prepared by dissolution and aging in an aqueous KOH/urea solution. A chitin multifilament is prepared by wet-spinning using a pilot-scale wet-spinning apparatus and aqueous alcohol/salt coagulation. After deacetylation, the chitosan multifilament possesses a dense structure and low crystallinity, but excellent mechanical properties. The chitin/chitosan multifilaments exhibit excellent cytocompatibilities and have promising prospects in biomedical applications. The method developed in this work provides a new approach for the pilot-scale wet-spinning of chitin/chitosan multifilaments.