Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo
Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo
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DOI：
10.3389/fneur.2019.00176
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发表时间：
2019-03-01
影响因子：
3.4
通讯作者：
Sone, Michihiko
中科院分区：
文献类型：
--
作者：
Nakada, Takafumi;Sugiura, Saiko;Sone, Michihiko
背景和目的：在水平管良性阵发性位置性眩晕（BPPV）中，杯丘石症表现为持续超过1分钟的背地方向改变性眼球震颤，而耳管结石导致持续<1分钟的向地性方向改变性眼球震颤。人们普遍认为，杯壶石症和管壶石症之间的区别是移位的耳石附着在半规管的壶杯上。多项研究表明 BPPV 与维生素 D 缺乏之间存在关系，但没有研究比较肾小管结石症和穹窿结石症患者之间的血清维生素 D 水平。本研究的目的是明确水平管结石病和水平管结石病患者血清维生素D水平的差异。方法：这项回顾性研究分别包括20名和15名水平管结石病患者。测量了 BPPV 急性期 25-羟基维生素 D [25(OH)D] 的血清水平。结果：肾小管结石和杯壶石症患者的平均 25(OH)D 血清水平分别为 13.2 +/- 1.4 和 20.4 +/- 1.6 ng/mL，在调整年龄和年龄后，差异具有统计学显着性 (p = 0.0014)。性别 （p = 0.0351）。耳管结石组和杯壶石症组分别有 20 名患者中的 18 名 (90%) 和 15 名患者中的 5 名 (33%) 被诊断为维生素 D 缺乏，并且这种差异也具有统计学意义 (p = 0.0005)。结论：我们发现耳管结石症患者的血清维生素 D 水平显着低于水平管杯结石症患者。
Background and Purpose: In the horizontal canal benign paroxysmal positional vertigo (BPPV), cupulolithiasis shows apogeotropic direction changing nystagmus lasting more than 1 min, while canalolithiasis leads to geotropic direction changing nystagmus lasting < 1 min. The difference between cupulolithiasis and canalolithiasis is widely accepted to be the attachment of the displaced otoconia to the cupula of a semicircular canal. Several studies have shown a relationship between BPPV and vitamin D deficiency, but no studies have compared serum levels of vitamin D between canalolithiasis and cupulolithiasis patients. The purpose of this study was to clarify the difference in vitamin D serum level between canalolithiasis and cupulolithiasis of the horizontal canal.Methods: This retrospective study included 20 and 15 patients with canalolithiasis and cupulolithiasis of the horizontal canal, respectively. Serum levels of 25-hydroxyvitamin D [25(OH)D] during the acute phase of BPPV were measured.Results: The mean 25(OH)D serum level in patients with canalolithiasis and cupulolithiasis was 13.2 +/- 1.4 and 20.4 +/- 1.6 ng/mL, respectively, and the difference was statistically significant (p = 0.0014), also after adjusting for age and sex (p = 0.0351). Eighteen out of 20 (90%) and 5 of 15 (33%) patients were diagnosed with vitamin D deficiency in the canalolithiasis and cupulolithiasis groups, respectively, and this difference was also statistically significant (p = 0.0005).Conclusion: We found that serum vitamin D level in patients with canalolithiasis was significantly lower than that in patients with cupulolithiasis of the horizontal canal.