INCREASED ACTIVATION OF PELVIC MACROPHAGES IN INFERTILE WOMEN WITH MILD ENDOMETRIOSIS
INCREASED ACTIVATION OF PELVIC MACROPHAGES IN INFERTILE WOMEN WITH MILD ENDOMETRIOSIS
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DOI：
10.1016/0002-9378(83)90720-2
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发表时间：
1983-01-01
影响因子：
9.8
通讯作者：
RAJ, S
中科院分区：
文献类型：
--
作者：
HALME, J;BECKER, S;RAJ, S
收集66名接受腹腔镜绝育术或诊断性腹腔镜检查的妇女的盆腔液，以评估不孕症。分离主要由巨噬细胞组成的细胞，计数并进行酸性磷酸酶和髓过氧化物酶的组织化学染色，作为细胞刺激的标志物。分析盆腔液的酸性磷酸酶、中性蛋白酶和可提取的前列腺素E2和F2 α。轻度子宫内膜异位症组巨噬细胞中酸性磷酸酶阳性染色比例高于生育组（46% vs. 15%）。轻度子宫内膜异位症患者盆腔液酸性磷酸酶和中性蛋白酶活性均高于正常生育者（P < 0.05，P < 0.01）。子宫内膜异位症组前列腺素的含量与生育组相比无显著性差异。结果表明，轻度子宫内膜异位症与巨噬细胞的活化有关，活性物质释放到腹腔液中可能是相关不孕症的原因。
Pelvic fluid was collected from 66 women undergoing laparoscopic sterilization or diagnostic laparoscopy for evaluation of infertility. Cells consisting mainly of macrophages were separated, counted and subjected to histochemical staining for acid phosphatase and myeloperoxidase as markers of cell irritation. Pelvic fluid was analyzed for acid phosphatase, neutral protease and extractable prostaglandin E2 and F2.alpha.. A higher proportion (46% vs. 15%) of the macrophages in the group with mild endometriosis exhibited positive staining for acid phosphatase as compared with the fertile group. Pelvic fluid from patients with mild endometriosis had higher acid phosphatase and neutral protease activity than that from fertile patients (P < 0.05, P < 0.01). The content of either prostaglandin was not significantly higher in the endometriosis group as compared with the fertile group. The results suggest that mild endometriosis is associated with activation of macrophages and release of active substances into peritoneal fluid may be responsible for the associated infertility.