Expression of E-cadherin and N-cadherin in surface epithelial-stromal tumors of the ovary distinguishes mucinous from serous and endometrioid tumors
Expression of E-cadherin and N-cadherin in surface epithelial-stromal tumors of the ovary distinguishes mucinous from serous and endometrioid tumors
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DOI：
10.1016/s0046-8177(97)90184-2
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发表时间：
1997-06-01
期刊：
影响因子：
3.3
通讯作者：
Salazar, H
中科院分区：
文献类型：
--
作者：
Soler, AP;Knudsen, KA;Salazar, H
本研究检查了最常见的卵巢上皮肿瘤中 E-钙粘蛋白和 N-钙粘蛋白的表达。细胞-细胞粘附分子钙粘蛋白家族的独特成员的同型相互作用在胚胎发育过程中将细胞分离到组织中，它们在肿瘤中的表达可用于追踪肿瘤细胞的组织发生。由于卵巢表面上皮是一种改良的间皮，我们推测E（上皮）-钙粘蛋白和N（神经，中胚层）-钙粘蛋白的表达可能为常见上皮性卵巢肿瘤有争议的起源提供线索。使用已充分表征的 E 和 N-钙粘蛋白单克隆抗体以及热诱导抗原修复方法在石蜡切片中进行免疫组织化学分析。我们发现浆液性肿瘤和子宫内膜样肿瘤均表达 E 和 N-钙粘蛋白。 Zn相反，粘液性肿瘤强烈表达E-钙粘蛋白，但不表达N-钙粘蛋白。 N-钙粘蛋白在浆液性肿瘤和子宫内膜样肿瘤中的存在可追溯到中胚层来源的卵巢表面上皮。粘液性肿瘤中 N-钙粘蛋白的缺乏清楚地将其与前者区分开来，表明其组织发生来自卵巢表面上皮以外的细胞谱系或与肿瘤转化相关的异常分化机制。版权所有 (C) 1997 W.B.桑德斯公司。
This study examines the expression of E-cadherin and N-cadherin in the most common epithelial tumors of the ovary. The homotypic interactions of distinctive members of the cadherin family of cell-cell adhesion molecules segregate cells into tissues during embryonic development, and their expression in tumors can be used to trace the histogenesis of tumor cells. Because the surface epithelium of the ovary is a modified mesothelium, we speculated that the expression of E (epithelial)-cadherin and N (neural, mesodermal)-cadherin may provide clues about the controversial origin of common epithelial ovarian tumors. Immunohistochemistry was performed in paraffin sections using well-characterized monoclonal antibodies to E and N-cadherin and heat-induced antigen-retrieval methods. We found that serous and endometrioid tumors express both E and N-cadherin. Zn contrast, mucinous tumors strongly express E-cadherin, but no N-cadherin. The presence of N-cadherin in serous and endometrioid tumors traces their origin to the mesoderm-derived ovarian surface epithelium. The absence of N-cadherin in mucinous tumors clearly distinguishes them from the former, suggesting histogenesis from a cell lineage other than the ovarian surface epithelium or aberrant differentiation mechanisms associated with neoplastic transformation. Copyright (C) 1997 by W.B. Saunders Company.