NORMAL MATURATION OF THE NEONATAL AND INFANT BRAIN - MR IMAGING AT 1.5 T
NORMAL MATURATION OF THE NEONATAL AND INFANT BRAIN - MR IMAGING AT 1.5 T
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DOI：
10.1148/radiology.166.1.3336675
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发表时间：
1988-01-01
期刊：
影响因子：
19.7
通讯作者：
NORMAN, D
中科院分区：
文献类型：
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作者：
BARKOVICH, AJ;KJOS, BO;NORMAN, D
研究了高场强磁共振（MR）成像显示的正常白质成熟模式。82名神经系统正常的婴儿进行了检查与1.5-T单位使用自旋回波T1加权和T2加权脉冲序列。婴儿的年龄从4天到2岁不等。对图像进行评估，以确定大脑14个解剖区域中白色物质相对于灰质的质的变化，并与患者的年龄相关。MR图像显示，脑成熟的变化是有序的，从脑干开始，向小脑和大脑发展。由脑髓鞘形成引起的变化在T1加权像上比在T2加权像上更早出现，这可能是因为发育中的髓鞘成分使T1缩短。T2加权图像上的后期变化与髓鞘形成的发展最相关，如组织化学方法所示。T1加权成像在监测出生后6-8个月的正常大脑发育方面最有用; T2加权成像在6个月后更有用。提出了大脑正常成熟的MR外观的里程碑。在所有检查的婴儿中，在心室三角区的上级和背侧可见持续性长T2弛豫时间区域，不应误认为缺血性改变。
The pattern of normal white-matter maturation as demonstrated with high-field-strength magnetic resonance (MR) imaging was investigated. Eighty-two neurologically normal infants were examined with a 1.5-T unit with use of spin-echo T1-weighted and T2-weighted pulse sequences. The infants ranged in age from 4 days to 2 years. The images were assessed for qualitative changes of white matter relative to gray matter in 14 anatomic areas of the brain and correlated with the patient''s age. The MR images showed that changes of brain maturation occur in an orderly manner, commencing in the brain stem and progressing to the cerebellum and the cerebrum. Changes caused by brain myelination were seen earlier on T1-weighted images than on T2-weighted images, possibly because of T1 shortening by the components of the developing myelin sheaths. The later changes on the T2-weighted images correlated best with the development of myelination as demonstrated with histochemical methods. T1-weighted images were most useful in the monitoring of normal brain development in the first 6-8 months of life; T2-weighted images were more useful after 6 months. The milestones in the MR appearance of normal maturation of the brain are presented. Persistent areas of long T2 relaxation times are seen superior and dorsal to the ventricular trigone in all infants examined and should not be mistaken for ischemic change.