Drug Use before and during Pregnancy in Japan: The Japan Environment and Children's Study.
Drug Use before and during Pregnancy in Japan: The Japan Environment and Children's Study.
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DOI：
10.3390/pharmacy5020021
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发表时间：
2017-04-10
期刊：
影响因子：
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通讯作者：
Japan Environment & Children’s Study Group
中科院分区：
文献类型：
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作者：
Nishigori H;Obara T;Nishigori T;Metoki H;Ishikuro M;Mizuno S;Sakurai K;Tatsuta N;Nishijima I;Fujiwara I;Arima T;Nakai K;Mano N;Kuriyama S;Yaegashi N;Japan Environment & Children’s Study Group
目的：阐明日本妊娠前和妊娠期间的药物使用情况。方法：日本环境与儿童研究（JECS）是一项正在进行的全国性出生队列研究。我们分析了来自JECS的数据，这些数据涉及在诊断妊娠前12个月、诊断妊娠至妊娠12周之间以及妊娠12周后使用药物的病例。结果：我们分析了97，464名孕妇的数据。在诊断怀孕前、诊断怀孕至怀孕12周之间以及怀孕12周后服用一种或多种药物和补充剂的孕妇比例分别为78.4%、57.1%和68.8%。不包括铁补充剂，叶酸和其他维生素和矿物质，服用补充剂的女性比例分别为75.3%，36.0%和51.7%。以下药物和补充剂在妊娠诊断前12个月内经常使用：市售解热药、镇痛药和/或治疗普通感冒的药物（34.7%），医院处方的解热药、镇痛药和/或治疗普通感冒的药物（29.8%），抗菌药物（14.0%）和抗过敏药（12.5%）。从妊娠诊断到妊娠第12周以及妊娠第12周后，经常使用以下药物和补充剂：叶酸（28.9%和26.2%），在医院开的退烧药、止痛药和/或治疗普通感冒的药中草药（6.0%和9.4%）、宫缩药（5.1%和15.2%）。结论：一项全国性队列研究的分析表明，日本孕妇服用药物的比例很高。需要进一步研究，以阐明在日本怀孕期间使用毒品与出生缺陷之间的关系。
Purpose: To elucidate drug use before and during pregnancy in Japan. Methods: The Japan Environment and Children’s Study (JECS) is an ongoing nationwide birth cohort study. We analyzed data from JECS involving cases where drugs were used for 12 months before pregnancy was diagnosed, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy. Results: We analyzed data from 97,464 pregnant women. The percentages of pregnant women who had taken one or more drugs and supplements before diagnosis of pregnancy, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy, were 78.4%, 57.1%, and 68.8% respectively. Excluding iron supplements, folic acid, and other vitamins and minerals, the percentages of women taking supplements were 75.3%, 36.0%, and 51.7% at each respective time point. The following drugs and supplements were frequently used for 12 months before pregnancy diagnosis: Commercially available antipyretics, analgesics, and/or medicine for treating common cold (34.7%), antipyretics, analgesics, and/or medicine for treating common colds, which were prescribed in hospitals (29.8%), antimicrobial drugs (14.0%), and anti-allergy drugs (12.5%). The following drugs and supplements were frequently used from the time of pregnancy diagnosis until week 12 of pregnancy, and after week 12 of pregnancy: folic acid (28.9% and 26.2%), antipyretics, analgesics and/or medicines for treating common cold, that were prescribed in hospitals (7.8% and 13.3%), Chinese herbal medicines (6.0% and 9.4%, and uterine relaxants (5.1% and 15.2%). Conclusions: The analysis of a nationwide cohort study showed that a high percentage of Japanese pregnant women were taking medicinal drugs. Further research is required to elucidate the relationship between drug use during pregnancy and birth defects in Japan.