Artificial microfluidic skin for in vitro perspiration simulation and testing
Artificial microfluidic skin for in vitro perspiration simulation and testing
复制标题
DOI：
10.1039/c3lc41231h
复制
发表时间：
2013-01-01
期刊：
影响因子：
6.1
通讯作者：
Heikenfeld, Jason
中科院分区：
文献类型：
--
作者：
Hou, Linlin;Hagen, Joshua;Heikenfeld, Jason
为了加快任何皮肤可穿戴材料、产品或设备的开发，与人体或动物试验相比，人工排汗（汗液）模拟器可以提供更好的易用性、成本、控制、灵活性和可重复性。本文报道了一种人体汗液模拟装置，包括微复制皮肤纹理。底部0.2 μ m的轨迹蚀刻聚碳酸酯膜层提供流速控制，而顶部的光固化层提供类似皮肤的特性，如汗孔密度、疏水性和湿滞性。该汗液模拟器的关键功能包括：恒定的“汗液”速率密度，没有气泡点变化，甚至可以降低到类似于1 L h(-1) m(-2)；复制了2个孔mm（-2）的孔密度和类似于50 μ m人皮肤的纹理；简单的重力流控制；低成本和一次性结构。
To expedite development of any skin wearable material, product, or device, an artificial perspiration (sweat) simulator can provide improved ease, cost, control, flexibility, and reproducibility in comparison to human or animal tests. Reported here is a human perspiration mimicking device including microreplicated skin-texture. A bottom 0.2 mu m track etched polycarbonate membrane layer provides flow-rate control while a top photo-curable layer provides skin-like features such as sweat pore density, hydrophobicity, and wetting hysteresis. Key capabilities of this sweat simulator include: constant 'sweat' rate density without bubble-point variation even down to similar to 1 L h(-1) m(-2); replication of the 2 pores mm(-2) pore-density and the similar to 50 mu m texture of human skin; simple gravity-fed flow control; low-cost and disposable construction.