Trajectories of co-occurring psychopathology symptoms in autism from late childhood to adulthood.
Trajectories of co-occurring psychopathology symptoms in autism from late childhood to adulthood.
复制标题
从儿童晚期到成年的自闭症中共同出现的心理病理学症状的轨迹。
DOI：
10.1017/s0954579420000826
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发表时间：
2020-10
影响因子：
3.3
通讯作者：
Lord C
中科院分区：
文献类型：
--
作者：
McCauley JB;Elias R;Lord C
鉴于青少年和成人自闭症谱系障碍（ASD）的并发率很高，研究这些精神病理症状的发展轨迹至关重要。使用来自一组参与者（n = 194）的数据，我们调查了从儿童期晚期到成年期共同发生的抑郁、焦虑和注意力缺陷多动障碍（ADHD）症状的轨迹，其中大多数参与者在儿童期早期首次被评估为ASD。此外，还研究了与这些症状轨迹相关的儿童预测因子和成人结果。使用基于群体的轨迹模型，我们发现两类不同的个体表现出这些共同出现的症状模式：一类在一段时间内表现出相当低的症状，另一类在一段时间内表现出不同波动的症状升高（ADHD症状开始时高但减少，焦虑症状高但稳定，抑郁症状波动但在成年早期达到临床显著水平）。所有的高轨迹班级都与9岁时的适应技能有关；语言智商预示着更高的焦虑和抑郁症状类别。在计入语言智商后，所有高症状轨迹类别都是客观成人结局的负向预测因子。这些发现要求对个体的需求进行广泛的考虑，包括能力水平、自闭症症状、行为和情感挑战。
Given high rates of co-occurring conditions in youth and adults with autism spectrum disorder (ASD), it is critical to examine the developmental trajectories of these symptoms of psychopathology. Using data from a cohort of participants (n = 194), most of whom were first assessed for ASD in very early childhood, we investigated the trajectories of co-occurring depressive, anxiety, and attention-deficit hyperactivity disorder (ADHD) symptoms from late childhood to adulthood. Additionally, childhood predictors and adult outcomes associated with these symptom trajectories were examined. Using group-based trajectory modeling, we found two distinct classes of individuals exhibiting each of these co-occurring symptom patterns: one class exhibited fairly low symptoms across time, and one class with elevated symptoms with varied fluctuation across time (ADHD symptoms starting high but decreasing, anxiety symptoms high and stable, and depressive symptoms fluctuating but peaking at clinically significant levels in young adulthood). All high trajectory classes were associated with age 9 adaptive skills; verbal IQ predicted higher anxiety and depressive symptom classes. After accounting for verbal IQ, all high symptom trajectory classes were negative predictors of objective adult outcomes. These findings call for wide-ranging considerations of the needs of individuals across ability levels, autism symptoms, and behavioral and emotional challenges.