Novel Method for Rapid Assessment of Cognitive Impairment Using High- Performance Eye-Tracking Technology
Novel Method for Rapid Assessment of Cognitive Impairment Using High- Performance Eye-Tracking Technology
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DOI：
10.1038/s41598-019-49275-x
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发表时间：
2019-09-10
影响因子：
4.6
通讯作者：
Morishita, Ryuichi
中科院分区：
文献类型：
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作者：
Oyama, Akane;Takeda, Shuko;Morishita, Ryuichi
痴呆症患者数量的迅速增加已成为全球健康挑战。越来越多的证据表明，早期诊断和及时干预可以延缓认知能力下降。痴呆症的诊断通常使用神经心理学测试来进行，例如由训练有素的检查员进行的简易精神状态检查（MMSE）。虽然这些传统的神经心理学测试有效且可靠，但作为痴呆症的常规筛查工具，它们既不简单，也不够短。在这里，我们利用眼球追踪技术开发了一个简短的认知评估。受试者观看显示器上显示的一系列短（178 秒）任务电影和图片，同时眼球跟踪设备记录他们的注视点，并根据注视图数据确定认知得分。通过基于眼动追踪的评估和神经心理学测试对 80 名参与者进行认知评分，其中包括 27 名认知健康对照 (HC)、26 名轻度认知障碍 (MCI) 患者和 27 名痴呆患者。基于眼动追踪的认知评分与神经心理学测试的评分密切相关，并且在检测 MCI 和痴呆症患者方面表现出良好的诊断性能。使用眼动追踪技术进行快速认知评估可以实现定量评分和认知障碍的灵敏检测。
A rapid increase in the number of patients with dementia has emerged as a global health challenge. Accumulating evidence suggests that early diagnosis and timely intervention can delay cognitive decline. The diagnosis of dementia is commonly performed using neuropsychological tests, such as the Mini-Mental State Examination (MMSE), administered by trained examiners. While these traditional neuropsychological tests are valid and reliable, they are neither simple nor sufficiently short as routine screening tools for dementia. Here, we developed a brief cognitive assessment utilizing an eye-tracking technology. The subject views a series of short (178 s) task movies and pictures displayed on a monitor while their gaze points are recorded by the eye-tracking device, and the cognitive scores are determined from the gaze plots data. The cognitive scores were measured by both an eye tracking-based assessment and neuropsychological tests in 80 participants, including 27 cognitively healthy controls (HC), 26 patients with mild cognitive impairment (MCI), and 27 patients with dementia. The eye tracking-based cognitive scores correlated well with the scores from the neuropsychological tests, and they showed a good diagnostic performance in detecting patients with MCI and dementia. Rapid cognitive assessment using eye-tracking technology can enable quantitative scoring and the sensitive detection of cognitive impairment.